| Identification | Back Directory | [Name]
16α-Hydroxy-24-methylene-3-oxo-5α-lanosta-7,9(11)-diene-21-oic acid | [CAS]
465-18-9 | [Synonyms]
Polyporenic acid C
16α-Hydroxy-24-methylene-3-oxo-5α-lanosta-7,9(11)-dien-21-oic acid
16α-Hydroxy-24-methylene-3-oxo-5α-lanosta-7,9(11)-diene-21-oic acid
3-Oxo-16α-hydroxy-24-methylene-5α-lanosta-7,9(11)-diene-21-oic acid
16alpha-Hydroxy-24-methylene-3-oxo-5alpha-lanosta-7,9(11)-diene-30-oic acid | [Molecular Formula]
C31H46O4 | [MDL Number]
MFCD29904546 | [MOL File]
465-18-9.mol | [Molecular Weight]
482.695 |
| Chemical Properties | Back Directory | [Melting point ]
265-266℃ | [Boiling point ]
620.3±55.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.63±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
OWVUHYZGACFYHI-SUIRJFICNA-N | [SMILES]
C1(=O)C([C@@]2([H])[C@](C)(CC1)C1C([C@]3([C@@](CC=1)(C)[C@@H]([C@H](C)CCC(=C)C(C)C)[C@H](O)C3)C(O)=O)=CC2)(C)C |&1:3,5,11,12,16,17,26,r| | [CAS DataBase Reference]
465-18-9 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Poria cocos. | [Uses]
Polyporenic acid C is a lanostane-type triterpenoid isolated from P. cocos. Polyporenic acid C induces cell apoptosis through the death receptor-mediated apoptotic pathway without the involvement of the mitochondria. Polyporenic acid C is promising agent for lung cancer therapy[1]. | [Biological Activity]
Polyporenic acid C is a lanostane-type triterpenoid isolated from P. cocos. It induces apoptosis through the death receptor-mediated apoptotic pathway without the involvement of mitochondria. It has the potential to be used in lung cancer research. | [target]
PARP | Caspase | PI3K | Akt | p53 | [storage]
4°C, protect from light | [References]
[1] Ling H, et al. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.Mol Carcinog.?2009 Jun;48(6):498-507. DOI:10.1002/mc.20487 |
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