| Identification | Back Directory | [Name]
ARMEPAVINE | [CAS]
524-20-9 | [Synonyms]
R-Armepavine
Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]- | [Molecular Formula]
C19H23NO3 | [MDL Number]
MFCD30551962 | [MOL File]
524-20-9.mol | [Molecular Weight]
313.39 |
| Chemical Properties | Back Directory | [Melting point ]
149-150° | [alpha ]
D20 -117.6° (CHCl3) (Knabe); D27 -103.2° (Farber) | [Boiling point ]
460.5±45.0 °C(Predicted) | [density ]
1.151±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.99±0.15(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades[1]. | [Definition]
ChEBI: Armepavine is a member of isoquinolines. | [IC 50]
p65 | [References]
[1] Weng TC, et al. Inhibitory effects of armepavine against hepatic fibrosis in rats. J Biomed Sci. 2009 Sep 2;16:78. DOI:10.1186/1423-0127-16-78 |
|
|