| Identification | Back Directory | [Name]
4-(Hydroxyamino)-4-oxobutanoic acid | [CAS]
4743-99-1 | [Synonyms]
Tofacitinib Impurity 208
N-Hydroxysuccinamidic acid
4-(Hydroxyamino)-4-oxobutanoic acid
3-(Hydroxyaminocarbonyl)propionic acid
Butanoic acid, 4-(hydroxyamino)-4-oxo- | [Molecular Formula]
C4H7NO4 | [MOL File]
4743-99-1.mol | [Molecular Weight]
133.1 |
| Chemical Properties | Back Directory | [Melting point ]
82-86 °C(Solv: acetonitrile (75-05-8)) | [density ]
1.436±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
5.28±0.10(Predicted) |
| Questions And Answer(Q&A) | Back Directory | [Preparation]
To a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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