| Identification | More | [Name]
4-Amino-2,6-dichloropyrimidine | [CAS]
10132-07-7 | [Synonyms]
2,4-DICHLORO-6-AMINO PYRIMIDINE
2,6-Dichloro-4-aminopyrimidine
2,6-DICHLOROPYRIMIDIN-4-AMINE
4-AMINO-2,6-DICHLOROPYRIMIDINE
2,6-dichloro-4-pyrimidinamin
4-Amino-2,6-dichloropyrimidine 97%
2,6-Dichloro-pyrimidin-4-ylamine
4-AMINO-2,6-DIMETHOXYPYRIMIDINESULPHADIMETHOXINE
4-Amino-2,6-dichloropyrimidine ,97%
2,6-Dichloropyrimidine-4-amine | [EINECS(EC#)]
233-369-3 | [Molecular Formula]
C4H3Cl2N3 | [MDL Number]
MFCD00038015 | [Molecular Weight]
163.99 | [MOL File]
10132-07-7.mol |
| Questions And Answer | Back Directory | [Synthesis]
For the synthesis of 4-amino-2,6-dichloropyrimidine, the conventional method starts from its hydroxyl precursor, 4-amino-2,6-dihydroxypyrimidine. In the presence of phosphorus oxychloride, the hydroxyl group on the pyrimidine ring is replaced with a chlorine unit through a deoxychlorination process. It should be noted that this route requires high temperatures for optimal results. Furthermore, after the reaction, the reaction system needs to be adjusted to a weakly basic state to prevent salt formation, which would reduce the yield. |
| Chemical Properties | Back Directory | [Melting point ]
258-267 °C | [Boiling point ]
323.5±22.0 °C(Predicted) | [density ]
1.606±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Powder or Crystalline Powder | [pka]
-0.86±0.10(Predicted) | [color ]
White to pale brown | [Water Solubility ]
Slightly soluble in water. | [Detection Methods]
HPLC | [InChI]
InChI=1S/C4H3Cl2N3/c5-2-1-3(7)9-4(6)8-2/h1H,(H2,7,8,9) | [InChIKey]
UPVBKNZVOJNQKE-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(Cl)=CC(N)=N1 | [CAS DataBase Reference]
10132-07-7(CAS DataBase Reference) | [EPA Substance Registry System]
10132-07-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline powder | [Uses]
It is used in the Suzuki coupling of 5-chloro-2-methoxyphenyl boronic acid with 4-amino-2,6-dichloropyrimidine yielded aminochloropyrimidine. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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