ChemicalBook--->CAS DataBase List--->477908-53-5

477908-53-5

477908-53-5 Structure

477908-53-5 Structure
IdentificationBack Directory
[Name]

Cy3 NHS Ester
[CAS]

477908-53-5
[Synonyms]

Cy7-SE
Cy7 dye
Sulfo-Cy7-SE
Sulfo-Cy7-SE, >95%
Sulfo-Cyanine7 Succinimidyl Ester
2-[7-[1-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3,5-heptatrien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
[Molecular Formula]

C39H45N3O10S2
[MDL Number]

MFCD29472575
[MOL File]

477908-53-5.mol
[Molecular Weight]

779.92
Chemical PropertiesBack Directory
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

DMF: soluble; DMSO: soluble; Ethanol: soluble
[form ]

A crystalline solid
[color ]

Light brown to black
[Appearance]

Dark green solid
[ex/em]

748/774 nm
[ε(extinction coefficient)]

200,000 L⋅mol−1⋅cm−1
[Φ(quantum yield)]

0.24
[InChIKey]

ROGODJHHEBREAB-UHFFFAOYSA-N
[SMILES]

C(N1C(C(C)(C)C2=CC(S(O)(=O)=O)=CC=C12)=CC=CC=CC=CC1C(C2=CC(S([O-])(=O)=O)=CC=C2[N+]=1CC)(C)C)CCCCC(=O)ON1C(CCC1=O)=O
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H317
[Precautionary statements ]

P280-P305+P351+P338
[HS Code ]

32049010
Hazard InformationBack Directory
[Description]

Cy7-NHS ester is a near IR dye.

[Chemical Properties]

Appearance: Dark green solid
ex/em: 748/774 nm
Extinction coefficient (ε): 200,000 L??mol??1??cm??1
Quantum yield (Φ): 0.24
[Uses]

CY7-SE is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2].
[Definition]

ChEBI: A C7-cyanine dye having differentially-substituted 2-indolyl units at each end.
[References]

[1] Ptaszek M. Rational design of fluorophores for in vivo applications. Prog Mol Biol Transl Sci. 2013;113:59-108. DOI:10.1016/B978-0-12-386932-6.00003-X
[2] Shindy, H. A. (2017). Fundamentals in the chemistry of cyanine dyes: A review. Dyes and Pigments, 145, 505–513. doi:10.1016/j.dyepig.2017.06.029
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