| Identification | Back Directory | [Name]
(S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide | [CAS]
479232-57-0 | [Synonyms]
TC OT 39
(S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide
(2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide
1-Pyrrolidinecarboxamide, N-[[4-[(4,10-dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-, (2S)- | [Molecular Formula]
C32H40N8O2S | [MDL Number]
MFCD28133368 | [MOL File]
479232-57-0.mol | [Molecular Weight]
600.78 |
| Hazard Information | Back Directory | [Uses]
TC OT 39 is a non-peptide oxytocin agonist. | [in vivo]
TC OT 39 (50 mg/kg, 75 mg/kg; i.p.; 4 times during 8-9 days) significantly decreases the marble burying at dose of 50 mg/kg, and shows overt sedative-like effects at dose of 75 mg/kg in C57BL/6J mice[1].
Marble burying is based on the natural instinct of rodents to bury objects, commonly used in preclinical research to assess anxiety-like behavior in rodents[1].
| [IC 50]
Avprla vasopressin receptor: 300 nM (Ki); Oxytocin Receptor: 180 nM (EC50) | [storage]
Store at -20°C |
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