| Identification | Back Directory | [Name]
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt | [CAS]
479347-86-9 | [Synonyms]
3-dione . 2Na
NBQX (sodium salt)
FG 9202 disodium salt
6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2
6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2;3-DIONE . 2NA;FG 9202 DISODIUM SALT
Benzo[f]quinoxaline-7-sulfonamide,1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-,sodium salt(1:2) | [Molecular Formula]
C24H14N8Na2O12S2 | [MOL File]
479347-86-9.mol | [Molecular Weight]
716.524 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C Freezer | [solubility ]
Soluble in H2O | [form ]
crystalline solid | [color ]
Orange | [Water Solubility ]
Soluble to 100 mM in water | [Stability:]
Store in Freezer at -20°C |
| Hazard Information | Back Directory | [Chemical Properties]
Deep Red-Brown Solid | [Uses]
A potent and discriminating antagonist for AMPA binding sites. | [Biological Activity]
nbqx disodium salt is a potent, highly selective and competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) receptors (ampars). the ampar is one type of ionotropic glutamate receptors, well known to be involved in various neurological disorders such as alzheimer disease, schizophrenia, and epilepsy, by mediating long-term potentiation, excitotoxicity, or both. inhibition of ampars with nbqx shows neuroprotective and anticonvulsant activity.1. fukushima k, tabata y, imaizumi y, et al. characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. journal of biomolecular screening, 2014, 19(8): 1174-1184.2. chen w, li ys, gao j, et al. ampa receptor antagonist nbqx decreased seizures by normalization of perineuronal nets. plos one, 2016, 11(11): e0166672. | [in vivo]
NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2].
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1].
| Animal Model: | Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2] | | Dosage: | 20 mg/kg | | Administration: | IP; for 3 days | | Result: | Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
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| [storage]
-20°C |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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Energy Chemical
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http://www.energy-chemical.com |
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InvivoChem
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13549236410 |
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