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483-34-1

483-34-1 Structure

483-34-1 Structure
IdentificationBack Directory
[Name]

(S)-Isocorypalmine
[CAS]

483-34-1
[Synonyms]

2-DM
Corydalis L
l-Isocorypalmine
(-)-Isocorypalmine
(S)-Isocorypalmine
(?)-Isocorypalmine
2-O-Desmethyl-L-THP
Tetratydrocolumbamine
O10-Methylstepholidine
l-Tetrahydrocolumbamine
(S)-Tetrahydrocolumbamine
(13aS)-5,8,13,13a-Tetrahydro-3,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-2-ol
(13aS)-3,9,10-Trimethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quinolizine-2-ol
6H-Dibenzo[a,g]quinolizin-2-ol, 5,8,13,13a-tetrahydro-3,9,10-trimethoxy-, (13aS)-
(S)-3,9,10-TriMethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinolin-2-ol
[13aS,(-)]-5,8,13,13a-Tetrahydro-3,9,10-trimethoxy-6H-dibenzo[a,g]quinolizine-2-ol
(13aS)-3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol
[Molecular Formula]

C20H23NO4
[MDL Number]

MFCD01718123
[MOL File]

483-34-1.mol
[Molecular Weight]

341.4
Chemical PropertiesBack Directory
[Melting point ]

240-241℃
[density ]

1.29
[storage temp. ]

Refrigerator
[solubility ]

Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated)
[Boiling point ]

501.2±50.0 °C(Predicted)
[form ]

Solid
[pka]

10.18±0.20(Predicted)
[color ]

White to Off-White
Hazard InformationBack Directory
[Description]

This Menispermaceous alkaloid is found in the EtOH extract of Bornean Tino_x0002_miscium petiolare and crystallizes as colourless crystals from Me2CO. The 0- methyl derivative is identical with (-)-Tetrahydropalmatine, m.p. 141-2°C.
[Uses]

A metabolite of the isoquinoline alkaloid biosynthesis pathway.
[Definition]

ChEBI: (S)-tetrahydrocolumbamine is a berberine alkaloid consisting of columbamine having four extra hydrogens at positions 5, 8, 13 and 13a and (S)-configuration. It is a berberine alkaloid and an organic heterotetracyclic compound. It is functionally related to a columbamine.
[target]

cAMP | Antifection | Dopamine Receptor
[References]

Tomita, Furukawa.,J. Pharm. Soc., Japan, 87,881 (1967)
Safety DataBack Directory
[Toxicity]

LD50 intravenous in mouse: 133mg/kg
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