| Identification | Back Directory | [Name]
3-Amino-6-bromopyrazine-2-carboxylic acid | [CAS]
486424-37-7 | [Synonyms]
3-AMINO-6-BROMOPYRAZINE-2-CARB
3-Amino-6-bromopyrazine-2-carboxylicaci
3-AMino-6-broMo-2-pyrazinecarboxylic Acid
3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID
2-Pyrazinecarboxylic acid, 3-amino-6-bromo-
3-Amino-6-bromopyrazine-2-carboxylicacid,98%
3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID, 95+%
3-Amino-6-bromopyrazine-2-carboxylic acid ISO 9001：2015 REACH
2-Amino-5-bromo-3-carboxypyrazine, 2-Amino-5-bromo-3-carboxy-1,4-diazine | [EINECS(EC#)]
802-115-9 | [Molecular Formula]
C5H4BrN3O2 | [MDL Number]
MFCD08275681 | [MOL File]
486424-37-7.mol | [Molecular Weight]
218.01 |
| Chemical Properties | Back Directory | [Melting point ]
178-183℃ | [Boiling point ]
397.8±42.0 °C(Predicted) | [density ]
2.039±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Soluble in dimethyl sulfoxide and methanol. | [form ]
Solid | [pka]
3.26±0.10(Predicted) | [color ]
Pale yellow | [Sensitive ]
Light Sensitive | [InChI]
InChI=1S/C5H4BrN3O2/c6-2-1-8-4(7)3(9-2)5(10)11/h1H,(H2,7,8)(H,10,11) | [InChIKey]
MTNAQEKMSVDTAQ-UHFFFAOYSA-N | [SMILES]
C1(C(O)=O)=NC(Br)=CN=C1N |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [HS Code ]
2933998090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
3-Amino-6-bromopyrazine-2-carboxylic acid used to prepare 3-bromo-5-phenylpyrazine-2-amine. It serves as an intermediate in organic synthesis and pharmaceuticals. | [Synthesis]
Step 2: Methyl 3-amino-6-bromopyrazine-2-carboxylate (5.11 g, 22.02 mmol) and lithium hydroxide (2.637 g, 110.1 mmol) were dissolved in a mixed solvent of methanol (20 mL) and water (20 mL), heated to 90 °C, and the reaction was carried out for 2 hours. After completion of the reaction, the reaction mixture was cooled, neutralized with hydrochloric acid to pH neutral, and the precipitated solid was collected by filtration. The resulting 3-amino-6-bromopyrazine-2-carboxylic acid was used directly in the next step of the reaction without further purification (4.80 g, 99% yield). | [References]
[1] Patent: WO2011/143419, 2011, A1. Location in patent: Page/Page column 44-45
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2784 - 2788
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[4] Patent: WO2017/123588, 2017, A1. Location in patent: Paragraph 0031; 0032; 0033
[5] Patent: WO2010/54398, 2010, A1. Location in patent: Page/Page column 90 |
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