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486460-21-3

486460-21-3 Structure

486460-21-3 Structure
IdentificationMore
[Name]

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
[CAS]

486460-21-3
[Synonyms]

3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-1,2,4-TRIAZOLO-[4,3-A]PYRAZINE
3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4triazolo4,3-apyrazinehydrochloride
3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]piperazine Hydrochloride
3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE PHOSPHATE SALT 98% MINHPLC
3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDRO
[EINECS(EC#)]

610-429-0
[Molecular Formula]

C6H8ClF3N4
[MDL Number]

MFCD08460920
[Molecular Weight]

228.6
[MOL File]

486460-21-3.mol
Questions And AnswerBack Directory
[Preparation]

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine is synthesized from 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[3,3-a]pyrazine hydrochloride via a dehydration reaction under alkaline conditions.
[Uses]

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine is primarily used as an important intermediate in organic synthesis. The introduction of the trifluoromethyl group imparts excellent chemical and thermal stability to this compound, allowing it to react under relatively harsh conditions. Furthermore, it possesses certain biological and pharmacological activities, making it a potential candidate compound for drug development. Therefore, it has wide applications in organic synthesis, materials science, and drug development.
Chemical PropertiesBack Directory
[Boiling point ]

266∶C
[density ]

1.72
[Fp ]

115∶C
[storage temp. ]

2-8°C(protect from light)
[pka]

6.27±0.20(Predicted)
[CAS DataBase Reference]

486460-21-3(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Hazard Codes ]

Xi
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethanol-->Palladium-->Hydrazinium hydroxide solution-->polyphosphoric acid-->Trifluoroacetic anhydride-->2-Chloropyrazine
[Preparation Products]

Sitagliptin N-Boc IMpurity
Hazard InformationBack Directory
[Chemical Properties]

White crystalline powder
Spectrum DetailBack Directory
[Spectrum Detail]

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride(486460-21-3)1HNMR
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