| Identification | More | [Name]
2-HYDROXYHIPPURIC ACID | [CAS]
487-54-7 | [Synonyms]
[(2-HYDROXYBENZOYL)AMINO]ACETIC ACID
(2-HYDROXYBENZOYL)GLYCINE
2-HYDROXYHIPPURIC ACID
IFLAB-BB F1918-0024
O-HYDROXYHIPPURIC ACID
SALICYLGLYCINE
SALICYLGYCINE
SALICYLURIC ACID
TIMTEC-BB SBB000337
Glycine, N-(2-hydroxybenzoyl)-
Hippuric acid, o-hydroxy-
n-(2-hydroxybenzoyl)-glycin
n-(2-hydroxybenzoyl)glycine
N-o-Hydroxybenzoylglycine
n-salicyloyl-glycin
N-Salicyloylglycine
o-hydroxy-hippuricaci
ortho-Hydroxyhippuric acid
Salicyloylglycine
salicylurate | [EINECS(EC#)]
207-661-6 | [Molecular Formula]
C9H9NO4 | [MDL Number]
MFCD00002695 | [Molecular Weight]
195.17 | [MOL File]
487-54-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RTECS ]
MR8160000 | [HS Code ]
29242998 |
| Hazard Information | Back Directory | [Description]
Salicyluric acid is an N-acylglycine in which the acyl group is
specified as 2-hydroxybenzoyl. It has a role as a uremic toxin and a
human xenobiotic metabolite. It is a N-acylglycine and a secondary
carboxamide. It is functionally related to a glycine. It is a conjugate acid of a salicylurate. | [Chemical Properties]
Light gray crystalline powder | [Uses]
Metabolite of Salicylic Acid (S088125).
2-Hydroxyhippuric acid is a phenol marker. Can be associated with dietary intake or bacterial overgrowth.
Indicators of Detoxification: A conjugate of the amino acid glycine and hydroxybenzoic acid (salicylic acid). Intake of aspirin (salicylates) or the growth of salicylate-producing gastrointestinal bacteria may elevate levels. Also increased after the ingestion of the artificial sweetener aspartame (Nutrasweet). | [Definition]
ChEBI: An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl. | [Synthesis]
The synthesis of Salicyluric acid is as follows:
To a solution of 5 g of glycine in 50ml of 10%NaOH was stirred at room temperature upon slowaddition of salicyloyl chloride, and the resultingmixture was stirred overnight. Progress of the reaction was followed by TLC (hexane : ethylacetate, 7 : 3).Then the reaction mixture was treated with crushed iceupon stirring. Concentrated HCl was added dropwiseand stirring was continued until the mixture turnedacidic. For removing the residual benzoic acid the mixture was treated with 10-12 mL of CCl4, boiled and then filtered. A pinkish white solid was obtained, yield 90%, mp 165°C.
 | [storage]
-20°C |
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