| Identification | Back Directory | [Name]
[1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- | [CAS]
487064-35-7 | [Synonyms]
N-(1-Acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydroquinolin-6-yl)-[1,1'-biphenyl]-4-carboxamide
N-(1-Acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydroquinolin-6-yl)-[1,1'-biphenyl]-4-carboxamide
[1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- | [Molecular Formula]
C33H32N2O2 | [MOL File]
487064-35-7.mol | [Molecular Weight]
488.62 |
| Hazard Information | Back Directory | [Uses]
FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s)-protein-coupled human follicle-stimulating hormone (FSH) receptor. FSH receptor antagonist 1 exhibits an IC50 of 28 nM on a cell line expressing the human FSH receptor. FSH receptor antagonist 1 significantly inhibits follicle growth and ovulation in an ex vivo mouse model[1]. | [References]
[1] Straten NCR, et, al. Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor. J Med Chem. 2005 Mar 24;48(6):1697-700. DOI:10.1021/jm049676l |
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