| Identification | Back Directory | [Name]
Butin | [CAS]
492-14-8 | [Synonyms]
(-)-Butin
(S)-7,3',4'-Trihydroxyflavanone
(2S)-7,3',4'-Trihydroxyflavanone
7, 3', 4'-trihydroxydihydroflavone
butin (7, 3′, 4′-trihydroxydihydroflavone)
(S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one
(2S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, (S)-
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, (2S)- | [Molecular Formula]
C15H12O5 | [MOL File]
492-14-8.mol | [Molecular Weight]
272.25 |
| Chemical Properties | Back Directory | [Melting point ]
224-226℃ | [Boiling point ]
582.4±50.0 °C(Predicted) | [density ]
1.485 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
7.69±0.40(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
(-)-Butin is the S enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities[1][2]. | [Definition]
ChEBI: Butin is a trihydroxyflavanone in which the three hydroxy substituents are located at positions 3', 4' and 7. It is found in Acacia mearnsii, Vernonia anthelmintica and Dalbergia odorifera and has a protective affect against oxidative stress-induced mitochondrial dysfunction. It has a role as an antioxidant, a protective agent and a metabolite. It is a trihydroxyflavanone and a member of 4'-hydroxyflavanones. | [References]
[1] Duan J, et al. Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Sci Rep. 2017 Jan 27;7:41491. DOI:10.1038/srep41491
[2] Li P, et al. Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. Transl Neurosci. 2018 May 8;9:7-12. DOI:10.1515/tnsci-2018-0002 |
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