| Identification | Back Directory | [Name]
H-TYR-NH2 HCL | [CAS]
4985-46-0 | [Synonyms]
L-Tyr-NH2
H-TYR-NH2
TYROSINE-NH2
TYROSINAMIDE
H-TYR-NH2 HCL
L-TYROSINAMIDE
L-TYROSINE AMIDE
TYROSINE-NH2 HCL
H-Tyr-NH2 Hydrochloride
H-TYR-NH2 HCL USP/EP/BP
L-tyrosinamide free base
L-Tyrosine amide≥ 98% (HPLC)
L-TYROSINE AMIDE HYDROCHLORIDE
(S)-2-AMino-3-(4-hydroxyphenyl)propanaMide
(2S)-2-amino-3-(4-hydroxyphenyl)propanamide
(2S)-2-amino-3-(4-hydroxyphenyl)propionamide
(2S)-2-azanyl-3-(4-hydroxyphenyl)propanamide
BenzenepropanaMide, a-aMino-4-hydroxy-, (S)-
Benzenepropanamide, α-amino-4-hydroxy-, (αS)-
(alphaS)-alpha-Amino-4-hydroxybenzenepropanamide | [Molecular Formula]
C9H12N2O2 | [MDL Number]
MFCD00069935 | [MOL File]
4985-46-0.mol | [Molecular Weight]
180.2 |
| Chemical Properties | Back Directory | [Melting point ]
153.5°C | [Boiling point ]
313.03°C (rough estimate) | [density ]
1.1819 (rough estimate) | [refractive index ]
1.5373 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 10mg/mL; DMSO: 10mg/mL; PBS (pH 7.2): 10mg/mL | [form ]
A solid | [pka]
9.97±0.15(Predicted) |
| Hazard Information | Back Directory | [Description]
L-Tyrosine amide is a tyrosine derivative and chiral ligand that has been used in the in vitro selection of DNA aptamers for the development of aptamer-based biosensors. | [Chemical Properties]
White to off-white powder | [Uses]
L-Tyrosinamide is a derivative of Tyrosine, is an amino acid amide[1]. | [Definition]
ChEBI: An amino acid amide that is L-tyrosine in which the carboxy OH group is replaced by NH2. | [Synthesis]
General procedure for the synthesis of (S)-2-amino-3-(4-hydroxyphenyl)propionamide from L-tyrosine methyl ester hydrochloride: L-tyrosine methyl ester hydrochloride (1.16 g, 5 mmol) was added to a 50 mL reaction vessel with concentrated ammonia (40 mL), and the reaction was stirred for 4 hours at room temperature. Upon completion of the reaction, the ammonia was removed by rotary evaporation followed by rotary drying. The crude product was washed with anhydrous ethanol (20 mL x 2) followed by water. Finally, it was purified by column chromatography (silica gel, 200-300 mesh; unfolding agent ratio of ethyl acetate:methanol:ammonia = 300:10:15) to afford L-tyrosine amide in 86% yield. | [References]
[1] Vianini E, et al. In vitro selection of DNA aptamers that bind L-tyrosinamide. Bioorg Med Chem. 2001 Oct;9(10):2543-8. DOI:10.1016/s0968-0896(01)00054-2 |
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