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50-10-2

50-10-2 Structure

50-10-2 Structure
IdentificationBack Directory
[Name]

Oxyphenonium bromide
[CAS]

50-10-2
[Synonyms]

c5473
ba-5473
antrenil
antrenyl
oxifenon
oxyfenon
oxyphenon
Spasmophen
Oxyphenonium
OrpheuM broMide
antrenylbromide
OXYDIANIL YELLOW
OXYPHENONIUM BROMIDE
2-DIETHYLAMINOETHYL-A-CYCLOHEXYL-A-PHENYLGLYCOLATE METHOBROMIDE
2-(α-cyclohexylmandeloyloxy)ethyldiethyl(methyl)ammonium bromide
2-(alpha-cyclohexylmandeloyloxy)ethyldiethyl(methyl)ammonium bromide
2-((cyclohexylhydroxyphenylacetyl)oxy)-n,n-diethyl-n-methyl-ethanaminiub
DIETHYL(2-HYDROXYETHYL)METHYLAMMONIUM 2-PHENYLCYCLOHEXANEGLYCOLATE BROMIDE
diethyl(2-hydroxyethyl)methylammoniumbromidealpha-phenylcyclohexaneglycolat
ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,alpha-phenylcyclohexaneglyco
2-(2-Cyclohexyl-2-hydroxy-2-phenylacetyl)oxyethyldiethylmethylazanium bromide
2-[(CYCLOHEXYLHYDROXYPHENYLACETYL)OXY]-N,N-DIETHYL-N-ETHYLETHANAMINIUM BROMIDE
2-[(CYCLOHEXYLHYDROXYPHENYLACETYL)-OXY]-N,N-DIETHYL-N-METHYLETHANAMINIUM BROMIDE
2-[(Cyclohexylhydroxyphenylacetyl)oxy]-N,N,-diethyl-N-methylethylammonium bromide
[EINECS(EC#)]

200-010-7
[Molecular Formula]

C21H34BrNO3
[MDL Number]

MFCD00050259
[MOL File]

50-10-2.mol
[Molecular Weight]

428.4
Chemical PropertiesBack Directory
[Melting point ]

189-194° from ethyl acetate + alc
[density ]

1.2584 (rough estimate)
[refractive index ]

1.6200 (estimate)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

A solid
[color ]

White to Off-White
Hazard InformationBack Directory
[Uses]

anticholinergic, anticonvulsant
[Originator]

A-Spasm ,Acme Laboratories Ltd.
[Manufacturing Process]

1 mol cycloxehylhydroxyphenylacetic acid methyl ester was mixed with 1 mol 2-diethylaminoethanol in presence of 1 mol sodium methylate to give cycloxehylhydroxyphenylacetic acid 2-diethylamino-ethyl ester.
5 parts by weight of it was dissolved in 50 volumes glacial acetic acid and a gaseous methyl bromide was introduced. The mixture was heated to about 50°C and crystallization of cycloxehylhydroxyphenylacetic acid diethylaminoethyl ester methyl bromide has shortly after begun. On cooling the crystals was filtered off and recrystallized from mixture of ethyl acetate ant a little ethanol to give the oxyphenonium bromide. MP: 189°-191°C.
[Brand name]

Antrenyl (Novartis).
[Therapeutic Function]

Anticholinergic, Spasmolytic
[Safety Profile]

Poison by ingestion, intramuscular, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: change in heart rate. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Brí.
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

20/21/22
[Safety Statements ]

36
[WGK Germany ]

3
[RTECS ]

BP7625000
[Toxicity]

LD50 orl-rat: 995 mg/kg JPETAB 108,292,53
Spectrum DetailBack Directory
[Spectrum Detail]

Oxyphenonium bromide(50-10-2)1HNMR
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