| Identification | Back Directory | [Name]
N-[[2-Cyano-4-(2,2-dimethylpropylamino)pyrimidin-5-yl]methyl]-4-(4-methylpiperazin-1-yl)benzamide | [CAS]
501000-36-8 | [Synonyms]
Dutacatib
Unii-L3m76J6S37
N-[[2-Cyano-4-(2,2-dimethylpropylamino)pyrimidin-5-yl]methyl]-4-(4-methylpiperazin-1-yl)benzamide
Benzamide, N-[[2-cyano-4-[(2,2-dimethylpropyl)amino]-5-pyrimidinyl]methyl]-4-(4-methyl-1-piperazinyl)- | [Molecular Formula]
C23H31N7O | [MDL Number]
MFCD13195555 | [MOL File]
501000-36-8.mol | [Molecular Weight]
421.54 |
| Hazard Information | Back Directory | [Uses]
Dutacatib is inhibitor for SARS-CoV-2 3CLpro and cathepsin K, which exhibits antiviral activity and ameliorates the cancer-induced bone diseases[1][2]. | [References]
[1] Sousa S, et al., Bone-Targeted Therapies in Cancer-Induced Bone Disease. Calcif Tissue Int. 2018 Feb;102(2):227-250. DOI:10.1007/s00223-017-0353-5
[2] Dayan Elshan NGR, et al., Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead. J Med Chem. 2024 Feb 22;67(4):2369-2378. DOI:10.1021/acs.jmedchem.3c01938 |
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