| Identification | Back Directory | [Name]
PHA 408 | [CAS]
503555-55-3 | [Synonyms]
PHA 408
PHA-408 >=98% (HPLC)
8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide
8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide
1H-Benz[g]indazole-3-carboxamide, 8-[[[5-chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro- | [Molecular Formula]
C29H27ClFN7O2 | [MDL Number]
MFCD17166977 | [MOL File]
503555-55-3.mol | [Molecular Weight]
560.02 |
| Chemical Properties | Back Directory | [Boiling point ]
727.4±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [pka]
10.18±0.20(Predicted) | [color ]
white to beige | [InChIKey]
ZLEZHGHFWIHCGU-UHFFFAOYSA-N | [SMILES]
Fc1ccc(cc1)[n]2nc(c3c2c4c(ccc(c4)NC(=O)c5c(cnc(c5)N6CCN(CC6)C)Cl)CC3)C(=O)N |
| Hazard Information | Back Directory | [Uses]
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1]. | [Biological Activity]
PHA-408 is a potentselective I kappa B-kinase 2 (IKK-2) inhibitor. PHA-408 is a tight bindingATP competitive IKK-2 inhibitor with greater than 350-fold selectivity for IKK-2 vs IKK-1 (IC50 values of 10-40 nM at IKK-2 vs 14 μM at IKK-1). PHA-408 was shown to suppress inflammatory cellular eventsand to reduce inflammation in animal models of arthritis. | [IC 50]
IKK-2 | [storage]
Store at -20°C | [References]
[1] Rajendrasozhan S, et al. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther. 2010 Jun;23(3):172-81. DOI:10.1016/j.pupt.2010.01.002 |
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| Company Name: |
BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
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+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
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