| Identification | More | [Name]
3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium methyl sulfate | [CAS]
51-60-5 | [Synonyms]
3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE
3-[([DIMETHYLAMINO]CARBONYL)OXY]-N,N,N-TRIMETHYLBENZAMINIUM METHYL SULFATE
3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM BROMIDE
3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM METHYL SULFATE
(3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM BROMIDE
(3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE
(3-HYDROXYPHENYL)TRIMETHYLAMMONIUM BROMIDE DIMETHYL CARBAMATE
(3-HYDROXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE DIMETHYLCARBAMATE
3-[N,N-DIMETHYLCARBAMOYLOXY]-N,N,N-TRIMETHYLANILINIUM METHYL SULFATE
NEOSTIGIMINE BROMIDE
NEOSTIGMINE BROMIDE
NEOSTIGMINE METHYL SULFATE
NEOSTIGMINE METHYL SULPHATE
PROSTIGMINE
(3-(dimethylcarbamoyloxy)phenyl)trimethyl-ammoniumethylsulfate
(3-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamicester
(m-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamate
3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-benzenaminiumethylsulfat
3-(dimethylcarbamoxy)phenyltrimethylammoniummethylsulfate
ammonium,(m-hydroxyphenyl)trimethyl-,methylsulfate,dimethylcarbamate | [EINECS(EC#)]
200-109-5 | [Molecular Formula]
C12H19BrN2O2 | [MDL Number]
MFCD00011795 | [Molecular Weight]
303.2 | [MOL File]
51-60-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
R28:Very Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact .
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
CY1225000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
29242990 | [Hazardous Substances Data]
51-60-5(Hazardous Substances Data) | [Toxicity]
LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann) |
| Hazard Information | Back Directory | [Description]
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM).1 In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively).2 Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block.3 Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome. | [Chemical Properties]
Crystalline Solid | [Uses]
Cholinergic; miotic; antidote (curare) | [Definition]
ChEBI: Neostigmine methyl sulfate is an arylammonium sulfate salt. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor. | [Brand name]
Prostigmine (ICN). | [General Description]
Neostigmine methylsulfate,(m-hydroxyphenyl)trimethylammonium methylsulfatedimethylcarbamate or the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniummethylsulfate (Prostigminmethylsulfate), is a bitter, odorless, white, crystalline powder.It is very soluble in water and soluble in alcohol. Solutionsare stable and can be sterilized by boiling. The compound istoo hygroscopic for use in a solid form and thus is alwaysused as an injection. Aqueous solutions are neutral to litmus. | [Clinical Use]
The methylsulfate salt is used postoperatively as a urinarystimulant and in the diagnosis and treatment of myastheniagravis. | [Purification Methods]
Crystallise the sulfate from EtOH or Me2CO (m 143-144o). Its solubility in H2O is ~10%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.) |
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