| Identification | More | [Name]
PHENYL CARBAMATE | [CAS]
622-46-8 | [Synonyms]
PHENYL CARBAMATE
Phenylcarbamate,98+%
CARBAMICACID,PHENYLESTER
o-Phenyl carbamate | [EINECS(EC#)]
210-737-1 | [Molecular Formula]
C7H7NO2 | [MDL Number]
MFCD00007961 | [Molecular Weight]
137.14 | [MOL File]
622-46-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white to very slightly pink crystalline flakes | [Melting point ]
149-152 °C(lit.) | [Boiling point ]
251.96°C (rough estimate) | [density ]
1.2528 (rough estimate) | [refractive index ]
1.5030 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder | [pka]
12.33±0.50(Predicted) | [Water Solubility ]
Soluble in water. | [BRN ]
2042627 | [InChI]
1S/C7H7NO2/c8-7(9)10-6-4-2-1-3-5-6/h1-5H,(H2,8,9) | [InChIKey]
BSCCSDNZEIHXOK-UHFFFAOYSA-N | [SMILES]
NC(=O)Oc1ccccc1 | [CAS DataBase Reference]
622-46-8(CAS DataBase Reference) |
| Questions and Answers (Q&A) | Back Directory | [Uses]
Phenyl carbamate is used as various phenyl carbamate esters derived from amino acids, a dipeptide and amino acid esters and amides were prepared and assessed as potential prodrugs with the aim of protecting phenolic drugs against first-pass metabolism following per oral administration.
A tin-catalyzed transcarbamoylation of primary and secondary alcohols with phenyl carbamate proceeds smoothly in toluene at 90℃ to generate the corresponding carbamates in good yields. This mild method exhibits a broad functional-group tolerance.
Y. Ichikawa, Y. Morishita, S. Kusaba, N. Sakiyama, Y. Matsuda, K. Nakano, H. Kotsuki, Synlett, 2010, 1815-1818.
http://dx.doi.org/10.1055/s-0030-1258102
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