| Identification | More | [Name]
Wogonin | [CAS]
632-85-9 | [Synonyms]
5,7-dihydroxy-8-methoxy-2-phenyl-4h-1-benzopyran-4-one
5,7-DIHYDROXY-8-METHOXYFLAVON
5,7-DIHYDROXY-8-METHOXYFLAVONE
WOGONIN
5,7-dihydroxy-8-methoxy-2-phenyl-4h-1-benzopyran-4-on
vogonin
WOGONIN 98.0% BY HPLC
WOOGONIN
WOGONIN hplc
WILDYAMP.E
4H-1-Benzopyran-4-one,5,7-dihydroxy-8-methoxy-2-phenyl-
2-Phenyl-5,7-dihydroxy-8-methoxy-4H-1-benzopyran-4-one | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C16H12O5 | [MDL Number]
MFCD00017736 | [Molecular Weight]
284.26 | [MOL File]
632-85-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
203-206°C | [Boiling point ]
518.8±50.0 °C(Predicted) | [density ]
1.420±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
Yellow solid | [pka]
6.83±0.40(Predicted) | [color ]
Light Yellow to Yellow | [λmax]
319nm(EtOH)(lit.) | [InChIKey]
XLTFNNCXVBYBSX-UHFFFAOYSA-N | [LogP]
2.140 (est) | [CAS DataBase Reference]
632-85-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
It is easily soluble in methanol, ethanol, acetone and ethyl acetate, soluble in ethanol, acetic acid and chloroform, slightly soluble in benzene and water, insoluble in carbon disulfide and petroleum ether. It is derived from the root of Scutellaria baicalensis Georgi, a plant of the Lamiaceae family. | [Uses]
Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia. | [Definition]
ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. | [General Description]
Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots. | [Biochem/physiol Actions]
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction. | [storage]
Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
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