| Identification | Back Directory | [Name]
(1'S,2'S)-NICOTINE 1'-OXIDE | [CAS]
51095-86-4 | [Synonyms]
Nicotine-cis-N-oxide
(1'S,2'S)-NICOTINE 1'-OXIDE
(1S,2S)-syn-Nicotine N'-oxide
(1'S,2'S)-TRANS-NICOTINE 1'-OXIDE
(1'S,2'S)-trans-Nicotine-1'-N-oxide
3-[(1S,2S)-1-Methyl-1-oxido-2-pyrrolidinyl]pyridine
(1S-cis)-3-(1-Methyl-1-oxido-2-pyrrolidinyl)pyridine
(1S-cis)-3-(1-Methyl-2-pyrrolidinyl)pyridine N-Oxide
3-[(1S,2S)-1-Methyl-1-oxido-2-pyrrolidinyl]
pyridine
(1'S,2'S)-NICOTINE 1'-OXIDE AND (1'R,2'S)-NICOTINE 1'-OXIDE | [Molecular Formula]
C10H14N2O | [MDL Number]
MFCD00869528 | [MOL File]
51095-86-4.mol | [Molecular Weight]
178.23 |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Yellow Solid | [Melting point ]
182-183°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMF: 50 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | [form ]
A crystalline solid | [pka]
4.63±0.40(Predicted) | [color ]
White to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Yellow Solid | [Uses]
Nicotine-1’-N-oxide is a derivative of Nicotine (N412420) found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1’-N-oxide has also been identified as a metabolite of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1’-N-oxide (both diastereomers) or cotinine. The ratio of these two products has been suggested as an indicator of bladder cancer in humans.
| [Uses]
Nicotine-1’-N-oxide is a derivative of nicotine found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1’-N-oxide has also been identified as a metabolite of nicotine in animals and in man. The metabolism of nicotine | [Definition]
ChEBI: Trans-(S)-nicotine N(1')-oxide is an (S)-nicotine N(1')-oxide in which the N(1')-methyl group is on the opposite side of the pyrrolidine ring to the pyridine substituent. The major species at pH 7.3. |
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