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54-11-5

54-11-5 Structure

54-11-5 Structure
IdentificationMore
[Name]

L-Nicotine
[CAS]

54-11-5
[Synonyms]

(-)-1-METHYL-2-[3-PYRIDYL]PYRROLIDINE
1-METHYL-2-(3-PYRIDYL)PYRROLIDINE
3-(1-METHYL-2-PYRROLIDINYL)PYRIDINE
3-(N-METHYL-2-PYRROLIDINYL)PYRIDINE
3-((S)-1-METHYL-PYRROLIDIN-2-YL)-PYRIDINE
BLACK LEAF 40
L-1-METHYL-2-[3-PYRIDYL]PYRROLIDINE
L(-)-NICOTINE
L-NICOTINE
NICO SOAP
(-)-NICOTINE
NICOTINE
NO-FID
S-(-)-NICOTINE
XL ALL NICOTINE
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
1-methyl-2-(3-pyridal)-pyrrolidin
1-Methyl-2-(3-pyridiyl)pyrrolidine
[EINECS(EC#)]

200-193-3
[Molecular Formula]

C10H14N2
[MDL Number]

MFCD00006369
[Molecular Weight]

162.23
[MOL File]

54-11-5.mol
Chemical PropertiesBack Directory
[Appearance]

Nicotine is a pale yellow to dark brown, oily liquid. Slight, fishy or pyridine-like odor when warm. It is also available as a powder.
[Appearance]

Yellow Liquid
[mp ]

-80 °C
[bp ]

243-248 °C
[alpha ]

-166 º (c=neat)
[density ]

1.010 g/mL at 20 °C(lit.)
[refractive index ]

n20/D 1.5265(lit.)
[Fp ]

215 °F
[storage temp. ]

2-8°C
[solubility ]

ethanol: 50 mg/mL
[form ]

liquid
[color ]

yellow
[Water Solubility ]

MISCIBLE
[Usage]

Naturally-occuring isomer
[Sensitive ]

Air Sensitive & Hygroscopic
[Merck ]

14,6524
[BRN ]

82109
[CAS DataBase Reference]

54-11-5(CAS DataBase Reference)
[NIST Chemistry Reference]

3-(2-(N-methylpyrrolidinyl))pyridine(54-11-5)
[EPA Substance Registry System]

54-11-5(EPA Substance)
Questions And AnswerBack Directory
[alkaloid]

Nicotine is the substance in tobacco, nicotine content of tobacco because there are different species and origin, alkali content of tobacco each part is different. Cigarette factory scraps (tobacco powder) containing about 1% to 2% of the nicotine, tobacco stems and ribs smoke nicotine containing about 1% or so, people smoked cigarette contains nicotine amounted to about 3%. Pure nicotine is a colorless, oily liquid, miscible with water below 60 ℃, hydrate, more than 210 ℃ also miscible with water. Unstable nature, likely to be volatile, soluble in water and organic solvents. Nicotine is an alkaloid, so all properties of a base, to a compound made of salts and acids. In case of light and air turn brown and sticky, there is the odd smell and strong irritant.
[Toxicity]

Pure nicotine for people, livestock highly toxic rat oral LD50 of 50~60mg/kg, rabbit acute percutaneous LD5050mg/kg. Rabbit acute percutaneous LD50 for 50~60mg/kg, rabbit acute oral LD50 of 50mg/kg. Based on China's pesticide toxicity grading standards, is a highly toxic pesticides. However, because of volatile and rapidly decompose in air and light, and therefore can still be used to control pests on crops. Rapidly absorbed through the skin, inhalation and dermal exposure to toxic people. Toxic to birds. Young steelhead LC504mg/L, toxic to bees, but there insecticide effect. D. Pulex LC50 of 0.24mg/L. Fish and shellfish toxicity, mild injury to crops.
Safety DataBack Directory
[Hazard Codes ]

T+,N,Xn,F,Xi
[Risk Statements ]

R25:Toxic if swallowed.
R27:Very Toxic in contact with skin.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S7:Keep container tightly closed .
S16:Keep away from sources of ignition-No smoking .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
[RIDADR ]

UN 1654 6.1/PG 2
[WGK Germany ]

3
[RTECS ]

QS5250000
[HazardClass ]

6.1
[PackingGroup ]

II
[HS Code ]

29399910
[Hazardous Substances Data]

54-11-5(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
【Preparation Products】

Nicotinic acid
Hazard InformationBack Directory
[General Description]

Liquids. Toxic by inhalation, ingestion, and skin absorption. More dense than water. Flash points usually below 140°F. Contact may irritate skin, eyes, and mucous membranes. If available, obtain the technical name of the material from the shipping papers and contact CHEMTREC, (800-424-9300) for specific response information.
[Reactivity Profile]

An alkaloid produced from tobacco. Colorless, oily liquid, combustible, highly toxic. When heated to decomposition (-)-NICOTINE(54-11-5) emits very toxic fumes of carbon monoxide and oxides of nitrogen [Lewis, 3rd ed., 1993, p. 919].
[Air & Water Reactions]

Flammable. Slightly soluble in water.
[Hazard]

Toxic by ingestion, inhalation, and skin absorption. Gastrointestinal damage, central nervous system impairment, and cardiac impairment
[Health Hazard]

(-)-NICOTINE is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lbs.) person. It may be assumed that ingestion of 40-60 mg of nicotine is lethal to humans. There is fundamental difference between acute toxicity from use of nicotine as insecticide or from ingestion, and chronic toxicity that may be caused by prolonged exposure to small doses as occurs in smoking. Maternal smoking during pregnancy is associated with increased risk of spontaneous abortion, low birth weight and still-birth. Nicotine was found as a co-carcinogen in animals.
[Potential Exposure]

An alkaloid produced from tobacco. Nicotine is used in some drugs; and in tanning. At one time, nicotine was used in the United States as an insecticide and fumigant; however, it is no longer produced or used in the United States for this purpose.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Fire Hazard]

There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, (-)-NICOTINE emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames.
[Shipping]

UN1654 Nicotine, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
[Incompatibilities]

Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with strong acids. Attacks some forms of plastics, rubber, and coatings.
[Waste Disposal]

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Nicotine(54-11-5).msds
Spectrum DetailBack Directory
[Spectrum Detail]

L-Nicotine(54-11-5) 1H NMR
L-Nicotine(54-11-5) 13C NMR
L-Nicotine(54-11-5) IR1
L-Nicotine(54-11-5) MS
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

L-Nicotine,99+%(54-11-5)
[Alfa Aesar]

(S)-(-)-Nicotine, 99%(54-11-5)
[Sigma Aldrich]

54-11-5(sigmaaldrich)
54-11-5 suppliers list
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