| Hazard Information | Back Directory | [Uses]
Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis [1][2][5]. | [in vivo]
Substance P (3-11) (30 nmol/kg, i.v. infusion) increases plasma histamine in rats[4].
| [References]
[1] Yanaihara N, et al. Immunological aspects of secretin, substance P, and VIP. Gastroenterology. 1977 Apr;72(4 Pt.2):803-10. PMID:838240
[2] Chappa AK, et al. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006 Jun;23(6):1201-8. DOI:10.1007/s11095-006-0068-1
[3] Ruff MR, et al. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 1985;6 Suppl 2:107-11. DOI:10.1016/0196-9781(85)90142-1
[4] Sertl K, et al. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis. 1988 Jul;138(1):151-9. DOI:10.1164/ajrccm/138.1.151
[5] Freed AL, et al. Investigation of substance P transport across the blood-brain barrier. Peptides. 2002 Jan;23(1):157-65. DOI:10.1016/s0196-9781(01)00592-7 |
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