| Identification | Back Directory | [Name]
Lynestrenol | [CAS]
52-76-6 | [Synonyms]
exluten
exluton
lynenol
LYNDIOL
Exlutena
exlutona
exlution
nsc-37725
org485-50
orgametil
orgametril
LYNESTRENO
linestrenol
LYNESTRENOL
LYNOESTRENOL
ETHINYLESTRENOL
ethynloestrenol
ethynylestrenol
LYNESTRENOL(RG)
Lynestrenol CRS
LYNESTRENOL(SH)
ethinyloestranol
ethinyloestrenol
3-desoxynorlutin
Lynestrenol (20 mg)
LYSINE HCL FEED GRADE
17-alpha-ethynylestrenol
17-alpha-ethynyloestrenol
4-ESTREN-17A-ETHINYL-17BETA-OL
19-Nor-4-pregnen-20-yn-17beta-ol
(17α)-19-Norpregn-4-en-20-yn-17-ol
19-Norpregn-4-en-20-yn-17-ol, (17α)-
4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL
17-alpha-ethynylestr-4-en-17-beta-ol
17-alpha-ethynyloestr-4-en-17-beta-ol
19-nor-17-alpha-pregn-4-en-20-yn-17-l
19-nor-17-alpha-pregn-4-en-20-yn-17-ol
(17-alpha)-19-norpregn-4-en-20-yn-17-ol
Lynestrenol for peak identification CRS
17-alpha-ethinyl-17-beta-hydroxyestr-4-ene
17-alpha-ethinyl-17-beta-hydroxyoestr-4-ene
17-alpha-ethynil-delta-4-estrene-17-beta-ol
19-nor-17-alpha-pregn-4-en-20-yn-17-beta-ol
delta(sup4)-17-alpha-ethinylestren-17-beta-ol
delta(sup4)-17-alpha-ethinyloestren-17-beta-ol
(8R,9S,10R,13S,14S,17S)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-Methyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol | [EINECS(EC#)]
200-151-4 | [Molecular Formula]
C20H28O | [MDL Number]
MFCD00051135 | [MOL File]
52-76-6.mol | [Molecular Weight]
284.44 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
158°C | [alpha ]
D -13° (chloroform) | [Boiling point ]
366.92°C (rough estimate) | [density ]
1.0083 (rough estimate) | [refractive index ]
1.4500 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Practically insoluble in water, soluble in acetone and in ethanol (96 per cent). | [form ]
neat | [pka]
13.12±0.40(Predicted) | [color ]
Crystals from MeOH | [Merck ]
14,5629 | [CAS DataBase Reference]
52-76-6 | [EPA Substance Registry System]
19-Norpregn-4-en20-yn-17-ol, (17.alpha.)-(52-76-6) |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
Progestogen;Antioestrogen | [Definition]
ChEBI: Lynestrenol is a steroid. It derives from a hydride of an estrane. | [Brand name]
Anacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar. | [World Health Organization (WHO)]
Lynestrenol, a synthetic progestogen, was introduced in the early
1960s as a component in oral contraceptive preparations. In 1967, as a result of
new regulations required by the United States Food and Drug Administration,
lynestrenol was submitted to long-term toxicity studies and by the early 1970s it
was shown to be associated with an increased incidence of mammary tumours in
beagle bitches which led to its withdrawal by at least one regulatory authority.
Subsequently the validity of the beagle bitch model as a predictor of
carcinogenicity of steroid contraceptives has been contested by many national
regulatory authorities and lynestrenol remains available in some countries for
contraceptive and other purposes.
(Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984) | [Safety Profile]
An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge |
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