ChemicalBook--->CAS DataBase List--->52428-09-8

52428-09-8

52428-09-8 Structure

52428-09-8 Structure
IdentificationBack Directory
[Name]

4 7-DIMETHOXY-1-INDANONE 97
[CAS]

52428-09-8
[Synonyms]

4 7-DIMETHOXY-1-INDANONE 97
4,7-dimethoxy-1H-inden-1-one
4,7-DIMETHOXY-2,3-DIHYDROINDEN-1-ONE
4,7-DIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE
2,3-Dihydro-4,7-dimethoxy-1H-inden-1-one
1H-Inden-1-one, 2,3-dihydro-4,7-dimethoxy-
[Molecular Formula]

C11H12O3
[MDL Number]

MFCD00757244
[MOL File]

52428-09-8.mol
[Molecular Weight]

192.21
Chemical PropertiesBack Directory
[Melting point ]

122-125 °C (lit.)
[Boiling point ]

352.6±42.0 °C(Predicted)
[density ]

1.179±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[form ]

solid
[Appearance]

Light yellow to yellow Solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H332-H335
[Precautionary statements ]

P261-P280-P305+P351+P338
[WGK Germany ]

3
[HS Code ]

2914500090
Hazard InformationBack Directory
[Uses]

4,7-Dimethoxy-1-indanone acts as a reagent for the synthesis and biological evaluation of indenopyrazine dicarbonitrile as inhibitors of deubiquitinating enzymes.
[Definition]

ChEBI: 4,7-dimethoxy-2,3-dihydroinden-1-one is a member of indanones.
[Synthesis]

3-(2,5-DIMETHOXYPHENYL)PROPIONIC ACID

10538-49-5

4 7-DIMETHOXY-1-INDANONE  97

52428-09-8

The general procedure for the synthesis of 4,7-dimethoxy-1-indanone from 2,5-dimethoxybenzenepropanoic acid was as follows: a mixture of 2,5-dimethoxybenzenepropanoic acid (4.68 g, 22.3 mmol) and polyphosphoric acid (PPA, 50.87 g, 24.8 mL) was stirred and reacted for 4.0 h at 80°C. Upon completion of the reaction, the mixture was slowly poured into 250 mL of ice water and extracted with ethyl acetate (EtOAc, 100 mL x 5). The organic layers were combined, washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with petroleum ether/ethyl acetate (v/v = 3/1) as eluent to afford 4,7-dimethoxy-1-indanone as a light yellow solid (3.0 g, 70.0% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (MS, ESI) m/z: 193.2 [M + H]+; 1H NMR (400 MHz, CDCl3) δ 7.52 (s, 1H), 6.87 (s, 1H), 3.90 (s, 3H), 3.88 (s, 3H), 3.00-2.97 (m, 2H), 2.68- 2.65 (m, 2H).

[References]

[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 4, p. 1051 - 1057
[2] Patent: WO2014/82379, 2014, A1. Location in patent: Page/Page column 139; 140; 141
[3] Patent: EP2730572, 2015, B1. Location in patent: Paragraph 0259; 0261
[4] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994, vol. 30, # 8, p. 905 - 915
[5] Khimiya Geterotsiklicheskikh Soedinenii, 1993, # 8, p. 1052 - 1062
Spectrum DetailBack Directory
[Spectrum Detail]

4 7-DIMETHOXY-1-INDANONE 97(52428-09-8)1HNMR
52428-09-8 suppliers list
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-2158073036
Website: www.dakenchem.com/
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Website: www.echemlin.cn
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.chemicalbook.com/ShowSupplierProductsList454175/0_EN.htm
Company Name: Richest Group Ltd
Tel: 18017061086
Website: www.chemicalbook.com/ShowSupplierProductsList664261/0_EN.htm
Company Name: CD Chemical Group Limited
Tel: +8615986615575 , +8615986615575
Website: http://www.codchem.com/
Company Name: Nextpeptide Inc
Tel: +86-0571-81612335 +8613336028439 , +8613336028439
Website: http://www.nextpeptide.com/
Company Name: Ningxia LabsChem Co., Ltd.
Tel: 0952-9294929 +8613895679378 , +8613895679378
Website: http://www.labschem.com
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +86-18621343501; +undefined18621343501 , +undefined18621343501
Website: http://www.acmec.com.cn/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Suzhou ARTK Medchem Co., Ltd.
Tel: +86-512-68323658 +86-18168183658 , +86-18168183658
Website:
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel: +8613817748580 , +8613817748580
Website: www.kean-chem.com
Company Name: DAYANG CHEM (HANGZHOU) CO.,LTD
Tel: +86-88938639 +86-17705817739 , +86-17705817739
Website: www.dycnchem.com
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: PharmaBlock Sciences (Nanjing),Inc.  
Tel: 025-86918202 4000255188
Website: http://www.pharmablock.com/
Company Name: Energy Chemical  
Tel: 021-021-58432009 400-005-6266
Website: http://www.energy-chemical.com
Tags:52428-09-8 Related Product Information
83-33-0 13336-31-7 40731-98-4

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.