| Identification | Back Directory | [Name]
Iriflophene | [CAS]
52591-10-3 | [Synonyms]
Iriflophene
Iriflophenone
4,2',4',6'-tetrahydroxybenzophenon
(4-Hydroxyphenyl)(2,4,6-trihydroxyphenyl)methanone
Methanone, (4-hydroxyphenyl)(2,4,6-trihydroxyphenyl)- | [Molecular Formula]
C13H10O5 | [MDL Number]
MFCD20260852 | [MOL File]
52591-10-3.mol | [Molecular Weight]
246.22 |
| Chemical Properties | Back Directory | [Melting point ]
210 °C | [Boiling point ]
482.4±33.0 °C(Predicted) | [density ]
1.526±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
7.03±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation[1][2]. | [Preparation]
Preparation by reaction of p-hydroxybenzonitrile with phloroglucinol, (15%) (Hoesch reaction). | [target]
Estrogen receptor | Progestogen receptor | [References]
[1] Monthakantirat O, et al. Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. J Nat Prod. 2005;68(3):361-364. DOI:10.1021/np040175c
[2] Kumar V, et al. Detection of intermediates through high-resolution mass spectrometry for constructing biosynthetic pathways for major chemical constituents in a medicinally important herb, Swertia chirayita. Nat Prod Res. 2015;29(15):1449-1455. DOI:10.1080/14786419.2015.1004175 |
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