ChemicalBook--->CAS DataBase List--->5274-68-0

5274-68-0

5274-68-0 Structure

5274-68-0 Structure
IdentificationMore
[Name]

Tetraethyleneglycol monododecyl ether
[CAS]

5274-68-0
[Synonyms]

BRIJ 30
BRIJ(R) 30
BRIJ(TM) 30
C12E4
DODECYL TETRAETHYLENE GLYCOL ETHER
DODECYLTETRAGLYCOL
POLYETHYLENE GLYCOL DODECYL ETHER
POLYOXYETHYLENE 4 LAURYL ETHER
TETRAETHYLENE GLYCOL DODECYL ETHER
TETRAETHYLENE GLYCOL MONODODECYL ETHER
TETRAETHYLENE GLYCOL MONO-N-DODECYL ETHER
2-(2-(2-(2-dodecyloxy-ethoxy)-ethoxy)-ethoxy)-ethanol
3,6,9,12-Tetraoxatetracosan-1-ol
LAURETH-4
Tetraethyleneglycol monododecyl ether 1mM Solution
TEGmono-n-dodecylether
Tetraethylenen glycol mono-n-dodecyl ether
dodecyltetraethylene glycol monoether
Tetraethyleneglycol monolauryl ether
Polyoxyethylene dodecyl alcohol ether
[EINECS(EC#)]

226-097-1
[Molecular Formula]

C20H42O5
[MDL Number]

MFCD00043063
[Molecular Weight]

362.54
[MOL File]

5274-68-0.mol
Questions And AnswerBack Directory
[Synthesis]

Synthetic route of Tetraethyleneglycol monododecyl ether

General synthetic method: Under argon protection, iodoalkane (1 eq.) was added to a DMF (40 mL) solution containing triethylene glycol or tritetraethylene glycol (1 eq.). The mixture was cooled to 0 °C, and sodium hydride (1.5 eq. 60% in mineral oil) was added. The mixture was stirred for 2 h, quenched with water, and extracted with ethyl acetate (20 mL × 2). The ethyl acetate phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (ethyl acetate-n-hexane). The sample was immediately used for the next reaction.

The synthesis of lauryl ether-4 was carried out using the general synthetic method described above. Tetraethylene glycol (2 mL, 11.59 mmol) was reacted with 1-iodododecane (4.42 g, 11.59 mmol) and sodium hydride (0.70 g, 17.38 mmol) to give lauryl ether-4 (2.18 g, 6.02 mmol, yield 52%), a colorless oil; Rf = 0.41 (ethyl acetate-n-hexane 3:2).
Chemical PropertiesBack Directory
[Appearance]

white solid or colourless liquid
[Melting point ]

14°C
[Boiling point ]

185°C/0.2mmHg(lit.)
[density ]

0.946 g/mL at 20 °C(lit.)
[refractive index ]

n20/D 1.453
[Fp ]

>230 °F
[storage temp. ]

2-8°C
[form ]

Liquid
[pka]

14.36±0.10(Predicted)
[color ]

Colorless to light yellow
[Odor]

at 100.00?%. mild alcoholic
[Stability:]

Stable. Incompatible with strong oxidizing agents.
[BRN ]

1791369
[Cosmetics Ingredients Functions]

ANTISTATIC
SURFACTANT - EMULSIFYING
SURFACTANT - CLEANSING
FRAGRANCE
[InChI]

1S/C20H42O5/c1-2-3-4-5-6-7-8-9-10-11-13-22-15-17-24-19-20-25-18-16-23-14-12-21/h21H,2-20H2,1H3
[InChIKey]

WPMWEFXCIYCJSA-UHFFFAOYSA-N
[SMILES]

CCCCCCCCCCCCOCCOCCOCCOCCO
[LogP]

4.204 (est)
[CAS DataBase Reference]

5274-68-0(CAS DataBase Reference)
[EPA Substance Registry System]

5274-68-0(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[RIDADR ]

UN 3082 9/PG 3
[WGK Germany ]

2
[RTECS ]

MD0875000
[F ]

3
[TSCA ]

TSCA listed
[HS Code ]

34029000
[Storage Class]

10 - Combustible liquids
[Hazard Classifications]

Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard InformationBack Directory
[Chemical Properties]

white solid or colourless liquid
[Uses]

Tetraethylene Glycol Monododecyl Ether is a well-characterized and non-ionic surfactant.
[Definition]

ChEBI: Tetraethylene glycol monododecyl ether is a poly(ethylene glycol).
Spectrum DetailBack Directory
[Spectrum Detail]

Tetraethyleneglycol monododecyl ether(5274-68-0)MS
Tetraethyleneglycol monododecyl ether(5274-68-0)1HNMR
Tetraethyleneglycol monododecyl ether(5274-68-0)13CNMR
Tetraethyleneglycol monododecyl ether(5274-68-0)IR1
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

5274-68-0(sigmaaldrich)
[TCI AMERICA]

Tetraethylene Glycol Monododecyl Ether,>98.0%(GC)(5274-68-0)
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