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60-29-7 Structure

60-29-7 Structure

Diethyl ether


Anaesthetic ether
Anesthesia ether
Anesthetic ether
Dwuetylowy eter

[Molecular Formula]

[MDL Number]

[Molecular Weight]

[MOL File]

Chemical PropertiesBack Directory

Clear liquid

Ethyl ether is a colorless, mobile, highly flammable, volatile liquid. Characteristic pungent odor. The Odor Threshold is 0.63 ppm.
[mp ]

-116 °C
[bp ]

34.6 °C(lit.)
[density ]

[vapor density ]

2.6 (vs air)
[vapor pressure ]

28.69 psi ( 55 °C)
[refractive index ]

n20/D 1.3530(lit.)
[Fp ]

-40 °F
[storage temp. ]

Store at RT.

Stable, but light-sensitive, sensitive to air. May contain BHT (2,6-di-tert-butyl-4-methylphenol) as a stabilizer. Substances to be avoided include zinc, halogens, halogen-halogen compounds, nonmetals, nonmetallic oxyhalides, strong oxidizing agents, chromyl chloride, turpentine oils, turps substitutes, nitrates, metallic chlorides. Extre
[Water Solubility ]

69 g/L (20 ºC)
[FreezingPoint ]

[Merck ]


ethyl ether is a solvent that may cause skin irritation. Although considered a non-comedogenic raw material, it is rarely used in cosmetics.
[CAS DataBase Reference]

60-29-7(CAS DataBase Reference)
[NIST Chemistry Reference]

Ethoxy ethane(60-29-7)
[EPA Substance Registry System]

60-29-7(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

[Risk Statements ]

R12:Extremely Flammable.
R19:May form explosive peroxides.
R22:Harmful if swallowed.
R66:Repeated exposure may cause skin dryness or cracking.
R67:Vapors may cause drowsiness and dizziness.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S29:Do not empty into drains .
S33:Take precautionary measures against static discharges .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .

UN 1155 3/PG 1
[WGK Germany ]


[F ]

[HazardClass ]

[PackingGroup ]

[HS Code ]

[Safety Profile]

Moderately toxic to humans by ingestion. Poison experimentally by subcutaneous route. Moderately toxic by intraperitoneal and intravenous routes. badly toxic by inhalation. Human systemic effects by inhalation: olfactory changes. Mutation data reported. A severe eye and moderate skin irritant. Ethyl ether is not corrosive or dangerously reactive. It must not be considered safe for indlviduals to inhale or ingest. It is a depressant of the central nervous system and is capable of producing intoxication, drowsiness, stupor, and unconsciousness. Death due to respiratory failure may result from severe and continued exposure. A very dangerous fire and explosion hazard when exposed to heat or flame. A storage hazard. It auto-oxidizes to form explosive polymeric 1 -oxy-peroxides. Explosive reaction with boron triazide, bromine trifluoride, bromine pentafluoride, perchloric acid, uranyl nitrate + light, wood pulp extracts + heat. Violent reaction or igmtion on contact with halogens (e.g., bromine, chlorine), interhalogens (e.g., iodine heptafluoride), oxidants (e.g., silver perchlorate, nitrosyl perchlorate, nitryl perchlorate, chromyl chloride, fluorine nitrate, permanganic acid, nitric acid, hydrogen peroxide, peroxodisulfuric acid, iodine(VⅡ) oxide, solum peroxide, ozone, and liquid air), sulfur and sulfur compounds (e.g., sulfur when dried with peroxidzed ether, sulfuryl chloride). Can react vigorously with acetyl peroxide, air, bromoazide, ClF3, CrO3, Cr(OCl)2, LiAlH2, NOClO4,02, NClO2, (H2so4 + permanganates), K2O2, [(C2H5)3di + air], [(CH3)d + air]. To fight fire, use alcohol foam, CO2, dry chemical. Used in production of drugs of abuse. When heated to decomposition it emits acrid smoke and irritating fumes. See also ETHERS.
[Hazardous Substances Data]

60-29-7(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Ethanol-->Sulfuric acid-->Sodium metabisulfite-->Diethyl sulfate-->Dehydrolyzing agent-->ETHYLENE
【Preparation Products】

Allyl methyl carbonate-->2-Methoxyphenylboronic acid-->2-Methoxy-5-pyridineboronic acid-->2-BROMO-4-NITRO(TRIFLUOROMETHOXY)BENZENE-->(6-ETHOXYPYRIDIN-3-YL)BORONIC ACID-->N-Boc-N,N-bis(2-chloroethyl)amine-->2-Amino-6-methyl-4-pyrimidinol-->2,2':5',2''-TERTHIOPHENE-->2,6-Difluorophenylboronic acid-->ethyl 1-methylpyrrole-2-carboxylate-->Benzo[b]thien-2-ylboronic acid-->3-Methylbenzylamine-->4-tert-Butylbenzoyl chloride-->4-(Trifluoromethyl)phenacyl bromide-->1,2-(Methylenedioxy)-4-nitrobenzene-->7-OXABICYCLO[2.2.1]HEPTANE-->N,N,N',N'-TETRAMETHYL-2-BUTENE-1,4-DIAMINE-->1,2-Epoxyoctane-->17beta-Hydroxy-17-methylandrosta-4,9(11)-dien-3-one-->3-(4-BROMOPHENOXY)PROPANOIC ACID-->2-Acetylthiazole-->A-MELANOCYTE STIMULATING HORMONE SYNTHETIC-->2-(4-Ethoxyphenyl)-2-methylpropanol-->N,N-diethyl-1-propynylamine-->Daidzein-->LACTAMIDE-->6-MORPHOLINONICOTINALDEHYDE-->2-PHENYL-2-PROPANOL-->1-Methyl-1H-pyrazole-5-carboxylic acid-->2,4-Dibromothiophene-->2-[5-(Benzyloxy)-1H-indol-3-yl]-2-oxoacetic acid ,97%-->2-Bromo-1-indanone-->ETHYLENEDIAMINE DIACETATE-->1,5-HEXADIENE-->Borane-pyridine complex-->Phosphomolybdic Acid-->Levonorgestrel-->ECGONINE HYDROCHLORIDE AMINO ALCOHOL POR TION-->methylated albumin-->Genistein
Hazard InformationBack Directory
[General Description]

A clear colorless liquid with an anesthetic odor. Flash point-49°F. Less dense than water and slightly soluble in water. Hence floats on water. Vapors are heavier than air. Used as a solvent and to make other chemicals.
[Reactivity Profile]

Occasional explosions have occurred when aluminum hydride was stored in ether. The explosions have been blamed on the presence of carbon dioxide impurity in the ether, [J. Amer. Chem. Soc. 70:877(1948)]. Diethyl ether and chromium trioxide react violently at room temperature. Solid acetyl peroxide in contact with ether or any volatile solvent may explode violently. A 5-gram portion in ether detonated while being carried, [Chem. Eng. News 27:175(1949)]. Nitrosyl perchlorate ignites and explodes with diethyl ether. A mixture of ether and ozone forms aldehyde and acetic acid and a heavy liquid, ethyl peroxide, an explosive, [Mellor 1:911(1946-1947)].
[Air & Water Reactions]

Highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. A mixture of liquid air and DIETHYL ETHER(60-29-7) exploded spontaneously, [MCA Case History 616(1960)].

CNS depressant by inhalation and skin absorption. Very flammable, severe fire and explosion hazard when exposed to heat or flame. Forms explosive peroxides. Explosive limits in air 1.85– 48%.
[Health Hazard]

Vapor inhalation may cause headache, nausea, vomiting, and loss of consciousness. Contact with eyes will be irritating. Skin contact from clothing wet with the chemical may cause burns.
[Potential Exposure]

Ethyl ether is used as a solvent for waxes, fats, oils, perfumes, alkaloids, dyes, gums, resins, nitrocellulose, hydrocarbons, raw rubber, and smokeless powder. It is also used as an inhalation anesthetic; a refrigerant; in diesel fuels; in dry cleaning; as an extractant; and as a chemical reagent for various organic reactions
[Fire Hazard]

Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. Decomposes violently when heated.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of salt water and induce vomiting. Do not make an unconscious person vomit

UN1155 Diethyl ether or Ethyl ether, Hazard Class: 3; Labels: 3-Flammable liquid

May form explosive mixture with air. Incompatible with strong acids; strong oxidizers halogens, sulfur, sulfur compounds, causing fire and explosion hazard. Can form peroxides from air, heat, sunlight; may explode when container is unstoppered or otherwise opened. Attacks some plastics, rubber and coatings. Being a nonconductor, chemical may accumulate static electric charges that may result in ignition of vapor.
[Waste Disposal]

Concentrated waste containing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxidesperforation of a container of the waste from a safe distance followed by open burning. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

ethyl ether(60-29-7).msds
Questions And AnswerBack Directory
[Chemical Properties]

Diethyl ether is inactive at room temperatures, but some reactions may also occur. Peroxides are prone to prolonged exposure to oxygen (or light) to become ether peroxide (also known as ether hydroperoxide). Peroxide ether is a viscous liquid that hardly evaporates. Antioxidants are often added in storage of ether to avoid the slow oxidation. Diethyl ether will crack in case of being oxidized violently. In the presence of catalysts, it can break down into aldehydes or acids. It reacts with an organic acid anhydride to form an ester in the presence of a catalyst, or reacts with an inorganic acid anhydride to form an ester without any catalyst. It can react with metal halides to produce addition compounds such as cerium chloride adduct 2(C2H5)2O•BeCl2. It can react with halogen to produce monohalogenated ethers and polyhaloethers. Ether can react with sulfuric acid generating an adduct.
[Medical uses]

It can be used to test the arm-to-lung blood circulation time. After being injected into the upper arm vein, the drug liquid goes from the right atrium, passes right ventricle to reach the lungs, and is then discharged from the respiratory tract. It normally takes 4 to 6 seconds for the patients to smell ether odor from the infusion moment (or 3 to 8 seconds).

【Usage and Dosage】
  • Take 1ml of ether and 2ml of 0.9% sodium chloride solution, mix them and then inject from the arm vein.
  • Adverse reactions such as temporary chest discomfort, cough, and local pain may occur.

  • Patients with potential heart failure are banned.
  • Do not inject Diethyl ether outside the blood vessels mistakenly.
  • Exposure to air or in storage for long, ether forms an explosive mixture of ether peroxides and aldehydes etc.

【Specifications】 Injection: 3ml.

  • Patients with severe intracranial hypertonia, acute inflammation of the upper respiratory tract, active tuberculosis, severe respiratory disease, cardiovascular disease, liver and kidney functional impairment, severe metabolic disorders and uncontrolled diabetes are strictly prohibited for Ether anesthesia. If the administration is excessive during the operation, respiratory dangers such as weakness of breathing, fall of blood pressure, rapid pulse and pupil dilation will occur.
  • Inhalation at 10% concentration can result in death. The maximum allowable concentration in the workplace is 400×10-6.

  • Rinse with soap when contact with eyes and skin. 
  • Help with the breathing using oxygen gas containing 5% carbon dioxide when breathing is abnormal and the face turns blue.
  • Drink hot tea and coffee to prevent vomiting.

Diethyl ether is produced by dehydrating ethanol at 300 °C in the presence of catalyst.
Spectrum DetailBack Directory
[Spectrum Detail]

Diethyl ether(60-29-7)MS
Diethyl ether(60-29-7)1HNMR
Diethyl ether(60-29-7)13CNMR
Diethyl ether(60-29-7)IR1
Diethyl ether(60-29-7)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

[Alfa Aesar]

Diethyl ether, Spectrophotometric Grade, 99+%(60-29-7)
[Sigma Aldrich]

60-29-7 suppliers list
Tags:60-29-7 Related Product Information
60-29-7 64-17-5 105-36-2 111-90-0 111-44-4 120-47-8 14128-54-2 693-04-9 119-23-3 14187-32-7 32413-08-4 615-83-8 5437-45-6 2999-46-4 535-11-5 615-96-3 600-00-0 5292-43-3