ChemicalBook--->CAS DataBase List--->5274-99-7

5274-99-7

5274-99-7 Structure

5274-99-7 Structure
IdentificationMore
[Name]

1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
[CAS]

5274-99-7
[Synonyms]

NSC 15149
TIMTEC-BB SBB003259
N-Benzoylisonipecotic acid
1-(benzoyl)isonipecotic acid
Benzoylpiperidinecarboxylicacid
1-Benzoylpiperidine-4-carbonsSre
N-Bz-4-Piperidinecarboxylic acid
1-Benzoyl-4-piperidinecarboxylic acid
N-Benzoyl-4-piperidinecarboxylic acid
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
1-BENZOYLPIPERIDINO-4-CARBOXYLIC ACID
4-piperidinecarboxylic acid, 1-benzoyl-
1-Benzoylpiperidine-4-carboxylicacid98%
1-Benzoylpiperidine-4-carboxylic acid 98%
1-phenylcarbonylpiperidine-4-carboxylic acid
1-(oxo-phenylmethyl)-4-piperidinecarboxylic acid
1-benzoylpiperidine-4-carboxylic acid(SALTDATA: FREE)
1-Benzoylisonipecotic acid, 1-Benzoyl-4-carboxypiperidine
[EINECS(EC#)]

226-099-2
[Molecular Formula]

C13H15NO3
[MDL Number]

MFCD00040747
[Molecular Weight]

233.26
[MOL File]

5274-99-7.mol
Chemical PropertiesBack Directory
[Melting point ]

144-146°C
[Boiling point ]

438.8±38.0 °C(Predicted)
[density ]

1.248±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[form ]

solid
[pka]

4.45±0.20(Predicted)
[color ]

White
[CAS DataBase Reference]

5274-99-7(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[Hazard Note ]

Irritant
[HazardClass ]

IRRITANT
[HS Code ]

2933399990
Spectrum DetailBack Directory
[Spectrum Detail]

1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID(5274-99-7)1HNMR
Hazard InformationBack Directory
[Synthesis]

Isonipecotic acid

498-94-2

Benzoyl chloride

98-88-4

1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID

5274-99-7

4-Piperidine carboxylic acid (129 mg, 1.0 mmol) and benzoyl chloride (140 mg, 1.0 mmol) were mixed in THF (5 mL) in the presence of triethylamine (0.32 mL, 2.5 mmol). The reaction mixture was placed in a microwave reactor and stirred at 70°C, 120 W power for 15 min. Upon completion of the reaction, the reaction mixture was acidified with 1 M HCl (10 mL) and subsequently extracted with dichloromethane (3 x 25 mL). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using hexane solution of 5% ethyl acetate and hexane solution of 80% ethyl acetate sequentially as eluent to afford 1-benzoylpiperidine-4-carboxylic acid in 94% yield as a white solid with melting point of 136-138°C. 1H NMR (400 MHz, CDCl3) δ 1.71-1.85 (m, 3H), 2.03- 2.06 (m, 1H), 2.59 (tt, 1H, J = 10.4, 4.1 Hz), 3.04-3.12 (m, 2H), 3.72-3.76 (m, 1H), 4.48-4.52 (m, 1H), 7.36-7.44 (m, 5H), 11.16 (br s, 1H).13C NMR (100 MHz. CDCl3) δ 40.4, 41.4, 46.8, 126.7, 128.3, 129.6, 135.3, 170.7, 178.3. HRMS (ESI): C13H14NO3 [M-H]? Calculated value, 232.0973; measured value, 232.0979.

[References]

[1] Bioorganic Chemistry, 2018, vol. 80, p. 245 - 252
[2] Tetrahedron Letters, 2014, vol. 55, # 12, p. 2037 - 2039
[3] Patent: WO2016/151484, 2016, A1. Location in patent: Paragraph 0327
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139
[5] Patent: US5948786, 1999, A
5274-99-7 suppliers list
Company Name: Changzhou Ditong Chemical Co.,Ltd
Tel: +86-0519-88299272
Website: http://www.edengenechem.com
Company Name: Wuhan Chemwish Technology Co., Ltd
Tel: 027-67849912
Website: www.chemicalbook.com/ShowSupplierProductsList485773/0_EN.htm
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel: +8613580539051 , +8613580539051
Website: www.yuhengpharm.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418671 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: HONG KONG IPURE BIOLOGY CO.,LIMITED
Tel: 86 18062405514 18062405514 , 18062405514
Website: www.chemicalbook.com/ShowSupplierProductsList1523002/0_EN.htm
Company Name: Blocksynth Pharmaceutical Technology Co.,Ltd
Tel: 0086-19817745290; +8619817745290 , +8619817745290
Website: http://www.blocksynth.com/
Company Name: Hefei Hirisun Pharmatech Co., Ltd
Tel: +8615056975894 , +8615056975894
Website: www.hirisunpharm.com
Company Name: Henan Alfa Chemical Co., Ltd
Tel: +8615838112936 , +8615838112936
Website: www.chemicalbook.com/manufacturer/henan-alfa-chemical-570/
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: DAYANG CHEM (HANGZHOU) CO.,LTD
Tel: +86-88938639 +86-17705817739 , +86-17705817739
Website: www.dycnchem.com
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel: +86-21-54098501
Website: www.sinch.com.cn
Company Name: ABCR GmbH & CO. KG
Tel: 49 721 95061 0
Website: www.abcr.de
Company Name: Mainchem Co., Ltd.  
Tel: +86-0592-6210733
Website: https://www.mainchem.com
Tags:5274-99-7 Related Product Information
776-75-0 5274-99-7

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.