| Identification | More | [Name]
1-Tetralone | [CAS]
529-34-0 | [Synonyms]
1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE
1-TETRALONE
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE
3,4-DIHYDRO-1(2H)-NAPHTHALENONE
3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE
ALPHA-TETRALONE
A-TETRALONE
KETOTETRAHYDRONAPHTHALENE
1(2H)-Naphthalenone
1,2,3,4-Tetrahydro-1-oxonaphthalene
1,2,3,4-Tetrahydronaphthalen-1-one
1-Oxo-1,2,3,4-tetrahydronaphthalene
1-Oxote-trahydronaphthalene
1-Oxotetralin
1-Tetrahydronathpalone
3,4-dihydro-1(2h)-naphthalenon
Tetralole
tetralone
1-Tetralone,97%
1(2H)-Naphthalenone, 3,4-dihydro- | [EINECS(EC#)]
208-460-6 | [Molecular Formula]
C10H10O | [MDL Number]
MFCD00001688 | [Molecular Weight]
146.19 | [MOL File]
529-34-0.mol |
| Chemical Properties | Back Directory | [Appearance]
clear amber to brown oily liquid | [Melting point ]
2-7 °C(lit.)
| [Boiling point ]
113-116 °C6 mm Hg(lit.)
| [density ]
1.099 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.568(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C | [solubility ]
Chloroform, Ethyl Acetate (Slightly) | [form ]
Liquid | [color ]
brown
| [Water Solubility ]
insoluble | [BRN ]
607374 | [InChI]
1S/C10H10O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6H,3,5,7H2 | [InChIKey]
XHLHPRDBBAGVEG-UHFFFAOYSA-N | [SMILES]
O=C1CCCc2ccccc12 | [CAS DataBase Reference]
529-34-0(CAS DataBase Reference) | [NIST Chemistry Reference]
1(2H)-Naphthalenone, 3,4-dihydro-(529-34-0) | [EPA Substance Registry System]
529-34-0(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P264-P270-P301+P312-P501 | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R20/22:Harmful by inhalation and if swallowed .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
QK4375000
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29143900 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Acute Tox. 4 Oral | [Hazardous Substances Data]
529-34-0(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Aluminum chloride-->Hydrogen fluoride-->polyphosphoric acid-->Phosphorus pentoxide-->Tin tetrachloride-->Butyryl chloride-->Gamma Butyrolactone-->4-Phenylbutyric acid-->1,2,3,4-Tetrahydronaphthalene-->5-Ethyl-2-methylpyridine-->Chromic acetate-->1(2H)-Naphthalenone, 3,4-dihydro-, 2,2-dimethylhydrazone-->(4,4-Difluoro-3-buten-1-yl)benzene-->4-Phenylbutyryl chloride | [Preparation Products]
(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid-->γ-Hydroxybutyrophenone-->7-Hydroxy-1-tetralone-->2,3-Dihydro-1,4-naphthoquinone-->(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol |
| Hazard Information | Back Directory | [Chemical Properties]
Clear amber to brown oily liquid | [Uses]
1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential. | [Production Methods]
Intramolecular acylation of 4-phenylbutyric acid to 1,2,3,4-tetrahydronaphthalen-1-one (1-Tetralone).
 | [Synthesis Reference(s)]
Tetrahedron Letters, 32, p. 4291, 1991 DOI: 10.1016/S0040-4039(00)92151-8 | [Purification Methods]
Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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