| Identification | More | [Name]
ISOSORBIDE DIMETHYL ETHER | [CAS]
5306-85-4 | [Synonyms]
1,4:3,6-DIANHYDRO-2,5-DI-O-METHYL-D-GLUCITOL
1,4:3,6-DIANHYDRO-2,5-O-DIMETHYL-D-GLUCITOL
1,4:3,6-DIANHYDROSORBITOL 2,5-DIMETHYL ETHER
2,5-DI-O-METHYL-1,4:3,6-DIANHYDRO-D-GLUCITOL
DIMETHYL ISOBORBIDE
DIMETHYL ISOSORBIDE
ISOSORBIDE DIMETHYL ETHER
O,O-DIMETHYLISOSORBIDE
2,5-dimethylisosorbide
Isosorbidedimethylether,98%
D-Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-
1,4:3,6-dianhydro-d-glucitol dimethyl ether
1,4:3,6-dianhydro-d-sorbitol dimethyl ether
1,4:3,6-Dianhydro-2,5-Di-0-methyl-D-glucitol
1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol, 1,4:3,6-Dianhydrosorbitol 2,5-dimethyl ether, 2,5-Di-O-methyl-1,4:3,6-dianhydro-D-glucitol, Dimethyl isosorbide
(1α,5α)-4β,8α-Dimethoxy-2,6-dioxabicyclo[3.3.0]octane
1,4:3,6-Dianhydro-2-O,5-O-dimethyl-D-glucitol
2-O,5-O-Dimethyl-1,4:3,6-dianhydro-D-glucitol | [EINECS(EC#)]
226-159-8 | [Molecular Formula]
C8H14O4 | [MDL Number]
MFCD00064828 | [Molecular Weight]
174.19 | [MOL File]
5306-85-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light yellow liquid | [Melting point ]
-70°C | [Boiling point ]
93-95 °C0.1 mm Hg(lit.)
| [density ]
1.15 g/mL at 25 °C(lit.)
| [vapor pressure ]
12.54Pa at 20℃ | [refractive index ]
n20/D 1.461(lit.)
| [Fp ]
227 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Liquid | [color ]
Clear colorless to light yellow | [PH]
7.0-8.0 (100g/l, H2O, 20℃) | [Optical Rotation]
[α]21/D +96.1°, c = 2 in chloroform | [Water Solubility ]
Soluble in water. | [BRN ]
80854 | [Cosmetics Ingredients Functions]
SOLVENT
VISCOSITY CONTROLLING | [InChI]
1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1 | [InChIKey]
MEJYDZQQVZJMPP-ULAWRXDQSA-N | [SMILES]
CO[C@H]1COC2[C@@H](COC12)OC | [LogP]
-1.62 | [Uses]
dimethyl isosorbide is a carrier, solvent, and viscosity controller. Its particular skin-penetrating ability opens the possibility of enhancing active substance efficacy in optical products. Its physical characteristics and solubility properties are superior to those of propylene glycol, glycerin, or ethyl alcohol. | [CAS DataBase Reference]
5306-85-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light yellow liquid | [Preparation]
Isosorbide dimethyl ether is synthesized from isosorbide by methylation.
Isosorbide dimethyl ether is obtained from stock like D-sorbitol, which is mainly derived from the hydrogenation of D-glucose.
Isosorbide dimethyl has a low level of toxicity and is referred to as a green solvent due to its production from renewable/raw material.
The boiling point of this solvent is high.
lt is used as a substitute to dimethyl sulfoxide,and dimethylformamide-like solvents. | [General Description]
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. Dimethyl isosorbide (DMI) is a biobased greener solvent and thus aligns with "Use of Renewable Feedstocks" and "Safer Solvents and Auxiliaries". Click here for more information. | [Flammability and Explosibility]
Nonflammable | [Synthesis]
The general procedure for the synthesis of (3S,3aR,6R,6aR)-6-methoxyhexahydrofuro[3,2-b]furan-3-ol, (3R,3aR,6S,6aR)-6-methoxyhexahydrofuro[3,2-b]furan-3-ol, and isosorbide dimethylether using ethylene glycol dimethyl ether and isosorbide as raw materials is as follows: isosorbide, 1,2-dimethoxyethane ( ethylene glycol dimethyl ether) and heteropolyacid were sequentially added into a stainless steel high-pressure reactor and the reactor was sealed. The reaction mixture was magnetically stirred at 150°C for 5 hours. The molar ratio of 1,2-dimethoxyethane to isosorbide was 20:1, and the mass ratio of heteropolyacid to isosorbide was 0.2:1. After the reaction was completed, the reactor was cooled to room temperature. The reaction mixture was analyzed using gas chromatography, and the conversion and yield of the methylated product of isosorbide was calculated as molar percentage (mol%) by internal standard method. | [References]
[1] Patent: CN105646514, 2016, A. Location in patent: Paragraph 0041; 0042; 0043; 0044; 0045; 0046
[2] RSC Advances, 2015, vol. 5, # 31, p. 24139 - 24143 |
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