| Identification | More | [Name]
DIPHENYLAMINE HYDROCHLORIDE | [CAS]
537-67-7 | [Synonyms]
DIPHENYLAMINE HYDROCHLORIDE
n-phenyl-benzenaminhydrochloride
diphenylammonium chloride
DiphenylamineHCl
N-PHENYLANILINE HYDROCHLORIDE | [EINECS(EC#)]
208-675-5 | [Molecular Formula]
C12H12ClN | [MDL Number]
MFCD00042007 | [Molecular Weight]
205.68 | [MOL File]
537-67-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [TSCA ]
TSCA listed | [HS Code ]
2921.44.7000 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent[1][2][3][4]. | [in vivo]
Diphenylamine hydrochloride is excreted in rats through urine and bile[1].
Diphenylamine (10 mg/kg, orally, single dose) hydrochloride lowers blood sugar in hyperglycemic rabbits[2]. | Animal Model: | Hyperglycemic rabbit[2] | | Dosage: | 10 mg/kg; single dose | | Administration: | Oral | | Result: | Reduced blood sugar by 61.4% two hours after administration. |
| [References]
[1] W E Alexander, et al. Metabolism of diphenylamine in the rat, rabbit and man. Food Cosmet Toxicol. 1965 Oct;3(4):571-9. DOI:10.1016/s0015-6264(65)80203-6
[2] M S Karawya, wt al. Diphenylamine, an antihyperglycemic agent from onion and tea. J Nat Prod. 1984 Sep-Oct;47(5):775-80. DOI:10.1021/np50035a003
[3] Safe S, et al. Identification of toxic impurities in commercial diphenylamine. Bull Environ Contam Toxicol. 1977 Feb;17(2):204-7. DOI:10.1007/BF01685551
[4] Masubuchi Y, et al. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2000 Mar;292(3):982-7. PMID:10688613 |
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