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538-75-0

538-75-0 Structure

538-75-0 Structure
IdentificationMore
[Name]

Dicyclohexylcarbodiimide
[CAS]

538-75-0
[Synonyms]

1,3-DICYCLOHEXYLCARBODIIMIDE
Bis(cyclohexyl)carbodiimide
CYCLOHEXANAMINE, N,N'-METHANETETRAYLBIS-
DCC
DCCD
DCCI
DICYCLOHEXYLCARBODIIMIDE
DICYCLOHEXYLCARBOXIMIDE(1,3-)
N,N-DICYCHOHEXYLCARBODIIMIDE
N,N-DICYCLOHEXYL CARBODIIMIDE
N,N'-DICYCLOHEXYLCARBODIIMIDE
N,N'-DICYLOHEXYLCARBODIIMIDE
Carbodicyclohexylimide
Carbodiimide, dicyclohexyl-
Dicyclimide
dicyclohexyl-carbodiimid
n,n’-dicyclohexylcarbodiimide,1msol.inn-methylpyrrolidone,peptidesynthesisgrade
n,n’-methanetetraylbis-cyclohexaamin
n,n’-methanetetraylbis-cyclohexanamin
N,N’-methanetetraylbis-Cyclohexanamine
[EINECS(EC#)]

208-704-1
[Molecular Formula]

C13H22N2
[MDL Number]

MFCD00011659
[Molecular Weight]

206.33
[MOL File]

538-75-0.mol
Chemical PropertiesBack Directory
[Appearance]

Colorless solid
[Appearance]

N,N0 -Dicyclohexylcarbodiimide (DCC) is a white crystalline solid. Odor is sweet and heavy.
[Melting point ]

34-35 °C(lit.)
[mp ]

34-35 °C(lit.)
[Boiling point ]

122-124 °C6 mm Hg(lit.)
[bp ]

122-124 °C6 mm Hg(lit.)
[density ]

1.247 g/mL at 25 °C
[refractive index ]

n20/D 1.48
[Fp ]

190 °F
[storage temp. ]

Store at RT.
[solubility ]

methylene chloride: 0.1 g/mL, clear, colorless
[form ]

Waxy Solid or Crystalline Mass
[color ]

White to pale yellow
[Stability:]

Stable, but moisture sensitive. Combustible. Incompatible with strong oxidizing agents. Avoid exposure to air or moisture.
[Water Solubility ]

Reaction
[Sensitive ]

Moisture Sensitive
[Detection Methods]

GC,NMR
[Merck ]

14,3096
[BRN ]

610662
[Contact allergens]

Used in peptide chemistry as a coupling reagent. It is both an irritant and a sensitizer and has caused contact dermatitis in pharmacists and chemists.
[CAS DataBase Reference]

538-75-0(CAS DataBase Reference)
[NIST Chemistry Reference]

Methanediimine, n,n'-dicyclohexyl-(538-75-0)
[Storage Precautions]

Moisture sensitive
[EPA Substance Registry System]

538-75-0(EPA Substance)
Hazard InformationBack Directory
[Chemical Properties]

Colorless solid
[Uses]

dicyclohexylcarbodiimide is used as a dehydrating agent at room temperature after a short reaction time, after the reaction product is dicyclohexylurea. the product is very small solubility in an organic solvent, so that easy separation of the reaction product.
[Uses]

N,N'-Dicyclohexylcarbodiimide is a carbodiimide used to couple amino acids during peptide synthesis. N,N'-Dicyclohexylcarbodiimide is used as a dehydrating agent for the preparation of amides, ketones , nitriles as well as in the inversion and esterification of secondary alcohols.
[Uses]

This product is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature. This product can also be used in synthesis of peptide and nucleic acid. It is easy to use this product to react with compound of free carboxy and amino-group into peptide. This product is widely used in medical, health, make-up and biological products, and other synthetic fields.
[Uses]

In the synthesis of peptides.
[Definition]

ChEBI: A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms.
[General Description]

White crystalline solid with a heavy sweet odor.
[Reactivity Profile]

N,N'-DICYCLOHEXYLCARBODIIMIDE(538-75-0) is an imide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). This compound is incompatible with acids and oxidizing agents. N,N'-DICYCLOHEXYLCARBODIIMIDE(538-75-0) reacts with water.
[Air & Water Reactions]

Sensitive to moisture.
[Hazard]

A poison by skin contact. Moderately toxic by ingestion and inhalation.
[Potential Exposure]

Laboratory reagent
[First aid]

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victimingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy
[Fire Hazard]

This chemical is probably combustible.
[Shipping]

UN2928 Toxic solids, corrosive, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, 8- Corrosive material, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required
[Incompatibilities]

Dust may for explosive mixture with air. Reacts with steam and water. N,N0 - Dicyclohexylcarbodiimide is an amine/imide: contact with strong oxidizers may cause fire and explosions. Incompatible with acids, strong bases, strong reducing agents (may form flammable gasses); azo and diazo compounds (may form toxic gases); chlorinated hydrocarbons; nitro compounds. Contact with mixture of acetic acid 1 dinitrogen trioxide may cause explosion. The combustion of amide compounds generate nitrogen oxides (NOx). In the presence of moisture, may attack metals and plastics.
[Waste Disposal]

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste facility. Although not a listed RCRA hazardous waste, this material may exhibit one or more characteristics of a hazardous waste and require appropriate analysis to determine specific disposal requirements. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements
Safety DataBack Directory
[Hazard Codes ]

T,Xn
[Risk Statements ]

R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
R40:Limited evidence of a carcinogenic effect.
R43:May cause sensitization by skin contact.
R41:Risk of serious damage to eyes.
R36/38:Irritating to eyes and skin .
R21:Harmful in contact with skin.
R24:Toxic in contact with skin.
R22:Harmful if swallowed.
R62:Possible risk of impaired fertility.
R37/38:Irritating to respiratory system and skin .
R10:Flammable.
R61:May cause harm to the unborn child.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S41:In case of fire and/or explosion do not breathe fumes .
S24:Avoid contact with skin .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S16:Keep away from sources of ignition-No smoking .
S53:Avoid exposure-obtain special instruction before use .
[RIDADR ]

UN 2922 8/PG 2
[WGK Germany ]

3
[RTECS ]

FF2160000
[F ]

3-8-10-21
[TSCA ]

Yes
[HazardClass ]

6.1
[PackingGroup ]

II
[HS Code ]

29251900
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Azabenzene-->Urea-->Carbon disulphide-->Cyclohexylamine-->DCHA-->N,N'-DICYCLOHEXYLUREA-->1,3-Dicyclohexylthiourea
[Preparation Products]

(S)-3-Aminoquinuclidine dihydrochloride-->Enalapril-->GLY-7-AMINO-4-METHYLCOUMARIN-->2-CYANOPYRIDINE-4-CARBOXALDEHYDE-->H-BETA-ALA-OTBU HCL-->NAPHTHOL AS-BI PHOSPHATE-->Captopril-->2,6-DICHLOROPHENETHYLISOCYANIDE-->1-(2-ISOCYANO-ETHYL)-4-METHYL-PIPERAZINE-->TERT-BUTYL METHYL MALONATE-->Isobutyric anhydride-->Lisinopril-->2-MORPHOLINOISONICOTINALDEHYDE-->1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]pyridinum hydroxide inner salt-->7-DIETHYLAMINO-3-THENOYLCOUMARIN-->Cefprozil hydrate-->4-ISOCYANOBENZOPHENONE-->TERT-BUTYL 3-HYDROXYPROPIONATE-->Docetaxel-->Cyclic AMP-->ANGIOTENSIN II, HUMAN-->3-CARBETHOXY-4-HYDROXYCOUMARIN-->7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid-->Beraprost-->Octreotide acetate-->Trandolapril-->Tetrabenzyl pyrophosphate-->Paroxetine-->Benexate Hydrochloride-->IBUTILIDE-->Latanoprost
Spectrum DetailBack Directory
[Spectrum Detail]

Dicyclohexylcarbodiimide(538-75-0)Raman
Dicyclohexylcarbodiimide(538-75-0)13CNMR
Dicyclohexylcarbodiimide(538-75-0)IR1
Dicyclohexylcarbodiimide(538-75-0)IR2
Dicyclohexylcarbodiimide(538-75-0)IR3
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

N,N'-Dicyclohexylcarbodiimide, 0.1M sol.in DCM, peptide synthesis grade(538-75-0)
[Alfa Aesar]

N,N'-Dicyclohexylcarbodiimide, 99%(538-75-0)
[Sigma Aldrich]

538-75-0(sigmaaldrich)
[TCI AMERICA]

N,N'-Dicyclohexylcarbodiimide  [for Peptide Synthesis],>98.0%(GC)(538-75-0)
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