| Identification | More | [Name]
N,N'-Diisopropylcarbodiimide | [CAS]
693-13-0 | [Synonyms]
1,3-DIISOPROPYLCARBODIIMIDE
DIC
DICI
DIPC
DIPCDI
DIPCI
N,N'-DIISOPROPYLCARBODIIMIDE
N,N-DIISOPROPYLCARBODIIMIDE
N,N'-Methanetetraylbis(1-methylethylamine)
n,n'-methanetetraylbis(2-propanamine)
PCI
Carbodiimide, diisopropyl-
diisopropyl-carbodiimid
Diisopropylcarbodiimide
n,n’-methanetetraylbis-2-propanamin
N,N'-Dissopropylcarbodiimide
N,N'-Diisopropyl carbodiimide(DIC)
N N'-DIISOPROPYLCARBODIIMIDE 99%
N,N'-DIISOPROPYLCARBODIIMIDE, CHEMDOSE &
DIC [N,N'-DIISOPROPYLCARBODIIMIDE] | [EINECS(EC#)]
211-743-7 | [Molecular Formula]
C7H14N2 | [MDL Number]
MFCD00065689 | [Molecular Weight]
126.2 | [MOL File]
693-13-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to pale yellow liquid | [Melting point ]
210-2120C (dec) | [Boiling point ]
145-148 °C(lit.)
| [density ]
0.815 g/mL at 20 °C(lit.)
| [vapor pressure ]
34.9hPa at 55.46℃ | [refractive index ]
n20/D 1.433(lit.)
| [Fp ]
93 °F
| [storage temp. ]
2-8°C
| [solubility ]
Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran. | [form ]
Liquid | [color ]
Clear colorless to yellow | [Sensitive ]
Moisture Sensitive | [Usage]
Used as an antineoplastic. Used in the treatment of malignant melanoma and sarcomas | [Detection Methods]
GC,NMR | [BRN ]
878281 | [Henry's Law Constant]
9.9×10-3 mol/(m3Pa) at 25℃, HSDB (2015) | [Stability:]
Volatile | [Major Application]
peptide synthesis | [InChI]
1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3 | [Contact allergens]
It is used in peptide chemistry as a coupling reagent. It
is very toxic and causes contact dermatitis in labora-
tory workers. | [InChIKey]
BDNKZNFMNDZQMI-UHFFFAOYSA-N | [SMILES]
CC(C)N=C=NC(C)C | [LogP]
4.11 at 20℃ | [CAS DataBase Reference]
693-13-0(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Propanamine, N,N'-methanetetraylbis-(693-13-0) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
693-13-0(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to pale yellow liquid | [Uses]
Activating reagent used in solid phase peptide synthesis. | [Uses]
This product is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature.
This product can also be used in synthesis of peptide and nucleic acid. It is easy to use this product to react with compound of free carboxy and amino-group into peptide.
This product is widely used in medical, health, make-up and biological products, and other synthetic fields.
| [Uses]
Used as an antineoplastic. Used in the treatment of malignant melanoma and sarcomas | [Definition]
ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms. | [Description]
Diisopropyl carbodiimide is used in peptide chemistry
as a coupling reagent. It is very toxic and caused
contact dermatitis in a laboratory worker. | [General Description]
N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator. | [reaction suitability]
reaction type: Coupling Reactions | [Synthesis]
Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.
|
| Safety Data | Back Directory | [Symbol(GHS) ]
   
GHS02,GHS05,GHS06,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H226-H317-H318-H330-H334 | [Precautionary statements ]
P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
T+,T,F | [Risk Statements ]
R10:Flammable.
R26:Very Toxic by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes.
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S38:In case of insufficient ventilation, wear suitable respiratory equipment .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 2929 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
FF2175000
| [F ]
10-21 | [Hazard Note ]
Flammable/Highly Toxic/ | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29252000 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 1 Inhalation
Eye Dam. 1
Flam. Liq. 3
Resp. Sens. 1
Skin Sens. 1 | [Hazardous Substances Data]
693-13-0(Hazardous Substances Data) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Dichloromethane-->Benzene-->Lead carbonate-->MOLECULAR SIEVES PACK 4A-->1,2-Diethoxydisulfane-->N,N'-Diisopropylthiourea | [Preparation Products]
4-(3-tert-Butyl-1,2,4-oxadiazol-5-yl)phenylboronic acid-->3-(2-Cyanoethylaminocarbonyl)phenylboronic acid-->4-(2-Cyanoethylaminocarbonyl)phenylboronic acid-->4-(3-tert-Butyl-1,2,4-oxadiazol-5-yl)benzaldehyde-->3-tert-Butyl-5-(4-bromophenyl)-1,2,4-oxadiazole-->4-(Piperidine-1-carbonyl)phenylboronic acid-->2-tert-Butyl-1,3-diisopropylisourea-->4,5-Imidazolidinedione, 2,2-dichloro-1,3-bis(1-methylethyl)--->Bis(N N'-diisopropylacetamidinato)nicke& |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
|