| Identification | More | [Name]
4-Hydroxypiperidine hydrochloride | [CAS]
5382-17-2 | [Synonyms]
4-HYDROXYPIPERIDINE HYDROCHLORIDE
4-PIPERIDINOL HYDROCHLORIDE
4-PIPIRIDINOL HYDROCHLORIDE
PIPERIDIN-4-OL HYDROCHLORIDE
TIMTEC-BB SBB004192
4-Hydroxypiperidine HCl
4-hydroxypiperidinium chloride
piperidin-4-ol hcl
4-PiperidinolHCl
2-FLUOROPHENYL HYDRAZINE BASE
4 HYDROXY PIPERADINE HCL | [EINECS(EC#)]
226-374-7 | [Molecular Formula]
C5H12ClNO | [MDL Number]
MFCD00035298 | [Molecular Weight]
137.61 | [MOL File]
5382-17-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
155-157 °C(lit.) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
methanol: soluble25mg/mL, clear, colorless | [form ]
powder to crystaline | [color ]
White to Orange to Green | [Water Solubility ]
very faint turbidity | [BRN ]
3908995 | [CAS DataBase Reference]
5382-17-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
3 | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester. | [Uses]
4-Hydroxypiperidine, HCl | [General Description]
4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor. | [Synthesis]
The general procedure for the synthesis of 4-hydroxypiperidine hydrochloride from N-Boc-4-hydroxypiperidine was as follows: tert-butyl 4-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol, 1.00 eq.) was mixed with a saturated HCl solution dissolved in 30 mL of 1,4-dioxane, and the reaction was stirred for 2 h at room temperature. Upon completion of the reaction, the mixture was concentrated in vacuum to afford 4-hydroxypiperidine hydrochloride (3.4 g, 99% yield) as an off-white solid. | [References]
[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0918; 0919
[2] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 120 |
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