| Identification | More | [Name]
6-AZAURIDINE | [CAS]
54-25-1 | [Synonyms]
2-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE
6-AZA-2,4-DIHYDROXYPYRIMIDINE RIBOSIDE
6-AZAURACIL RIBOSIDE
6-AZAURACIL RIBOSIDE MONOHYDRATE
6-AZAURIDINE
6-AZAURIDINE MONOHYDRATE
AZAURIDINE, 6-
2-beta-d-ribofuranosyl-1,2,4-triazin-3,5(2h,4h)-dion
2-beta-d-ribofuranosyl-as-triazine-3,5(2h,4h)-dione
3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazineriboside
4h)-dione,2-beta-d-ribofuranosyl-as-triazine-5(2h
4-triazine-3,5(2h,4h)-dione,2-beta-d-ribofuranosyl-2
6-azauracil1-riboside
6-azauracil-beta-d-riboside
6-azauracilribosid
6-azur
6-azuridine
azauridine
azur
nsc32074 | [EINECS(EC#)]
200-199-6 | [Molecular Formula]
C8H11N3O6 | [MDL Number]
MFCD00006472 | [Molecular Weight]
245.19 | [MOL File]
54-25-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
157-159 °C(lit.) | [Boiling point ]
388.15°C (rough estimate) | [density ]
1.4866 (rough estimate) | [refractive index ]
1.7950 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated), Pyridine (Slightly), Water | [form ]
Powder | [pka]
6.70(at 25℃) | [color ]
White | [Water Solubility ]
It is soluble in water. | [Merck ]
904 | [Stability:]
Hygroscopic | [InChI]
InChI=1/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/s3 | [InChIKey]
WYXSYVWAUAUWLD-YGWZKZRUSA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1N1N=CC(=O)NC1=O)O |&1:1,2,3,7,r| | [Uses]
Research on cell formation and cancer.
| [CAS DataBase Reference]
54-25-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
XY8575000
| [HS Code ]
29349990 | [Hazardous Substances Data]
54-25-1(Hazardous Substances Data) | [Toxicity]
LD50 oral in quail: > 316mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Definition]
ChEBI: 6-azauridine is a N-glycosyl-1,2,4-triazine. It has a role as an antineoplastic agent, an antimetabolite and a drug metabolite. | [General Description]
6-Azauridine is a pyrimidine nucleoside analog. | [Biochem/physiol Actions]
6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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