| Identification | Back Directory | [Name]
Dodecanoic acid ingenol ester | [CAS]
54706-70-6 | [Synonyms]
13-Oxyingenol dodecanoat
13-Oxyingenol Dodecanoate
Dodecanoic acid ingenol ester
Dodecanoic acid ingenol ester 54706-70-6
Dodecanoic acid, (1aR,2S,5R,5aR,6S,8aS,9R,10aS)-1,1a,2,5,5a,6,9,10-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-10aH-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-10a-yl ester | [Molecular Formula]
C32H50O7 | [MDL Number]
MFCD30478893 | [MOL File]
54706-70-6.mol | [Molecular Weight]
546.74 |
| Chemical Properties | Back Directory | [Melting point ]
>48°C (dec.) | [Boiling point ]
655.2±55.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.74±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Euphorbia lathyris L., a plant of the Euphorbiaceae family. | [Uses]
13-Oxyingenol Dodecanoate is a diterpene compound with antinematodal activity. Derivative of Ingenol (I655795), the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis. | [in vivo]
13-Oxyingenol-dodecanoate (2.5 mg/kg and 5 mg/kg; ip; every two days for two weeks) significantly inhibites the growth of transplanted tumors in a xenograft model by injecting H460 cells subcutaneously into nude mice[2].
| Animal Model: | xenograft model by injecting H460 cells into nude mice [2] | | Dosage: | 2.5 mg/kg and 5 mg/kg; every two days for two weeks | | Administration: | Intraperitoneal injection (i.p.) | | Result: | nhibited the growth of transplanted tumors in nude mice and had no significant toxic effects on organ function. |
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Henan Alfachem Co.,Ltd.
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www.chemicalbook.com/supplier/14555231/ |
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