| Identification | More | [Name]
QUININE SULFATE | [CAS]
549-56-4 | [Synonyms]
6-METHOXYCINCHONINE SULFATE
A-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINE-METHANOL SULFATE
QUININE BISULFATE
QUININE HEMISULFATE
QUININE SULFATE
QUININE SULPHATE
6’-methoxy-cinchonan-9-o(8alpha,9theta)-cinchonan-9-osulfate(1:1)(salt)
Quinine Bisulphate
quinine hydrogen sulphate
Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-, sulfate (1:1) (salt)
Sulfuric acid quinine | [EINECS(EC#)]
208-970-9 | [Molecular Formula]
C40H50N4O8S | [MDL Number]
MFCD00078499 | [Molecular Weight]
746.91 | [MOL File]
549-56-4.mol |
| Questions And Answer | Back Directory | [Chemical Properties]
Basic quinine sulfate is C40H50N4O8S; the dilIyrate, C40H50N4O8S·2H20, is dull needles or rods making a light and readily compressible mass that becomes brownish on exposure to light. Slightly soluble in chloroform and ether. Should be kept well closed and protected from light.
Uses are as a protective colloid in preparation of metallic colloidal solutions, photography, dyes, intermediates, synthetic drugs, medicine (antibacterial), process engraving, laboratory reagent, gas analysis (an oxygen absorber), reducing agent, and antioxidant in lubricating oils.
|
| Hazard Information | Back Directory | [Physical properties]
Crystals or crystalline powder. White when
fresh, but may acquire a brownish tint upon
exposure to air. | [Flammability and Explosibility]
Nonflammable | [in vivo]
Quinidine sulfate is rapidly absorbed, with peak plasma concentrations 60-90 min after an oral dose. Other salts (gluconate, polygalacturonate) are more slowly absorbed, with lower peak concentrations[2].
Quinidine sulfate is approximately 70-90 % bound to plasma proteins. It undergoes hepatic oxidative metabolism to form an N-oxide, a 3-hydroxy form, an O-demethyl form and 2'-quinidinone[2].
Quinidine sulfate inhibits metabolism of amphetamine in rats. Quinidine sulfate pretreatment results in a significant decrease in the excretion of p-hydroxyamphetamine at 24 and 48 h to 7.2 and 24.1% of the vehicle-control levels, respectively, accompanied by a significant increase in amphetamine excretion between 24 and 48 h to 542% of the control[3]. | [IC 50]
Plasmodium |
|
| Company Name: |
Mainchem Co., Ltd.
|
| Telephone: |
+86-0592-6210733 |
| Website: |
https://www.mainchem.com |
|