| Identification | Back Directory | [Name]
WAY-202196 | [CAS]
550997-55-2 | [Synonyms]
ERB-196
WAY-202196
1-Naphthalenecarbonitrile, 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxy- | [Molecular Formula]
C17H10FNO2 | [MDL Number]
MFCD30532578 | [MOL File]
550997-55-2.mol | [Molecular Weight]
279.27 |
| Chemical Properties | Back Directory | [Boiling point ]
497.0±45.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.10±0.20(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. | [Biological Activity]
WAY-202196 is a nonsteroidal selective estrogen receptor-beta (ERβ) agonist. | [in vivo]
WAY-202196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. It significantly reduces histopathologic evidence of injury to the gastrointestinal mucosal surface (0.7±0.1 vs. 2.3±0.2 for control; p< 0.05). The mucosal mass of 10-cm segments of small bowel mucosa shows better preservation of mucosal mass than control treatment (63±20 [ERB-196] vs. 31±24 [control]), but this difference fails to reach statistical significance (p<0.06). | [target]
| [References]
[1] Cristofaro PA, et al. WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Crit Care Med. 2006 Aug;34(8):2188-93. DOI:10.1097/01.CCM.0000227173.13497.56 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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