| Identification | More | [Name]
DL-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE | [CAS]
5619-09-0 | [Synonyms]
DL-TRYPTOPHAN METHYL ESTER HCL
DL-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE
DL-TRYPTOPHAN-OME HCL
H-DL-TRP-OME HCL
METHYL 2-AMINO-3-(1H-INDOL-3-YL)PROPANOATE HYDROCHLORIDE
TIMTEC-BB SBB003122
methyl2-amino-3-(1H-indol-3-yl)propanoateHCl
DL-Methyl Tryptophanate Monohydrochloride
NSC 34498 | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C12H15ClN2O2 | [MDL Number]
MFCD00066133 | [Molecular Weight]
254.71 | [MOL File]
5619-09-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
221-222 | [storage temp. ]
2-8°C | [solubility ]
Methanol, Water | [form ]
Solid | [color ]
Off-white to white | [Usage]
Amino acid derivative that may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550) | [InChI]
InChI=1S/C12H14N2O2.ClH/c1-16-12(15)10(13)6-8-7-14-11-5-3-2-4-9(8)11;/h2-5,7,10,14H,6,13H2,1H3;1H | [InChIKey]
XNFNGGQRDXFYMM-UHFFFAOYSA-N | [SMILES]
C12C=CC=CC=1NC=C2CC(N)C(=O)OC.Cl | [CAS DataBase Reference]
5619-09-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Amino acid derivative that may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550). | [Uses]
Amino acid derivative， D,L-Tryptophan Methyl Ester Hydrochloride may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550)
| [Synthesis]
The general procedure for the synthesis of L-tryptophan methyl ester hydrochloride from methanol and L-tryptophan was as follows: L-tryptophan (18.2 mmol) was dissolved in methanol (20 mL) at 0 °C with stirring. Thionyl chloride (1.6 mL, 22 mmol) was added slowly and dropwise over 10 min. Subsequently, the reaction mixture was gradually warmed to room temperature and heated under reflux conditions for 3 hours. Upon completion of the reaction, the solvent and volatiles were removed by distillation under reduced pressure. The resulting product was ground with ethyl acetate to give L-tryptophan methyl ester hydrochloride as a colorless solid in 100% yield. The product was a white solid with a yield of 4.63 g. Its 1H NMR (400 MHz, CD3OD) and 13C NMR (100 MHz, CD3OD) data were consistent with those reported in the literature, confirming the structure and purity of the product. | [References]
[1] Tetrahedron, 2001, vol. 57, # 51, p. 10181 - 10189
[2] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0111
[3] European Journal of Medicinal Chemistry, 2016, vol. 114, p. 318 - 327
[4] New Journal of Chemistry, 2018, vol. 42, # 16, p. 13549 - 13557
[5] Organic and Biomolecular Chemistry, 2014, vol. 12, # 41, p. 8280 - 8287 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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