| Identification | More | [Name]
5-Fluoro-2-oxindole | [CAS]
56341-41-4 | [Synonyms]
5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE
5-FLUORO-2-OXINDOLE
5-FLUORO-2-OXYINDOLE
5-FLUOROOXINDOLE
5-Fluoroindole-2-One
5-Fluoro-1,3-dihydro-indol-2-one
5-Fluorooxindole 98%
5-Fluorooxindole98%
5-FLUROOXINDOLE
2H-Indol-2-one,5-fluoro-1,3-dihydro-(9CI)
5-FLUORO-2-OXINDOLE, 98+%
5-FLUORO-2-NITROPHENYLACETATE
5-Fluoro-2-indolinone
2H-Indol-2-one, 5-fluoro-1,3-dihydro- | [EINECS(EC#)]
638-803-9 | [Molecular Formula]
C8H6FNO | [MDL Number]
MFCD02179598 | [Molecular Weight]
151.14 | [MOL File]
56341-41-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Crystalline | [Melting point ]
143-147 °C (lit.) | [Boiling point ]
307.2±42.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [storage temp. ]
Keep Cold | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Powder or Crystalline Powder | [pka]
12.99±0.20(Predicted) | [color ]
White to pale brown | [Detection Methods]
HPLC | [InChIKey]
DDIIYGHHUMKDGI-UHFFFAOYSA-N | [CAS DataBase Reference]
56341-41-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Hazard Note ]
Irritant/Keep Cold | [HazardClass ]
IRRITANT, KEEP COLD | [HS Code ]
29337900 |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Crystalline | [Uses]
5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis. | [Application]
5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors. | [Preparation]
synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%. |
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