| Identification | More | [Name]
4'-(Trifluoromethyl)acetophenone | [CAS]
709-63-7 | [Synonyms]
1-[4-(Trifluoromethyl)phenyl]ethan-1-one
4-ACETYLBENZOFLUORIDE
4-ACETYLBENZOTRIFLUORIDE
4'-(TRIFLUOROMETHYL)ACETOPHENONE
4-(TRIFLUOROMETHYL)ACETOPHENONE
P-TRIFLUOROMETHYLACETOPHENONE
1-(4-Trifluoromethyl-phenyl)-ethanone
1-[4-(Trifluoromethyl)phenyl]ethanone
Ethanone, 1-[4-(trifluoromethyl)phenyl]-
4'-(Trifluoromethyl)acetophenone,98%
4-(trifluoromehtyl)acetophenone
4'-(Trifluoromethyl)acetophenone 98%
4-TRIFLUOROMETHYL BENZYLDEHYDE | [EINECS(EC#)]
211-913-0 | [Molecular Formula]
C9H7F3O | [MDL Number]
MFCD00000401 | [Molecular Weight]
188.15 | [MOL File]
709-63-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White to faintly yellow low melting solid | [Melting point ]
30-33 °C(lit.) | [Boiling point ]
79-80 °C8 mm Hg(lit.) | [density ]
0.92
| [refractive index ]
1.4604
| [Fp ]
184 °F
| [storage temp. ]
Flammables area | [form ]
Low Melting Solid | [color ]
White to faintly yellow | [BRN ]
1870425 | [InChI]
1S/C9H7F3O/c1-6(13)7-2-4-8(5-3-7)9(10,11)12/h2-5H,1H3 | [InChIKey]
HHAISVSEJFEWBZ-UHFFFAOYSA-N | [SMILES]
CC(=O)c1ccc(cc1)C(F)(F)F | [CAS DataBase Reference]
709-63-7(CAS DataBase Reference) | [NIST Chemistry Reference]
4-CF3-C6H4-COCH3(709-63-7) |
| Questions And Answer | Back Directory | [Synthesis]
41.6 g of chlorocyclohexane (0.35 mol) were added dropwise to a suspension of 4.65 g of lithium particles (0.68 mol) in 350 g of THF at -55 °C, and an addition time of 2 hours was chosen. After >97% chlorocyclohexane conversion by GC (10 hours), a mixture of 38.3 g of 4-bromotrifluorotoluene (0.170 mol) and 7.0 g of acetonitrile (0.170 mol) was added dropwise at the same temperature for 15 minutes. After stirring for an additional 30 minutes at -50°C, the reaction mixture was slowly thawed to room temperature and subjected to an aqueous workup in a conventional manner. The yield of 4-trifluoromethylacetophenone after distillation was 81%. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29147090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
White to faintly yellow low melting solid | [Uses]
A labelled acetophenone with selective antimycobacterial activity. | [General Description]
The enantioselective addition of dialkylzinc to 4′-(trifluoromethyl)acetophenone mediated by 1,2-bis(hydroxycamphorsulfonamido)cyclohexenes in the presence of titanium tetraisopropoxide has been investigated. Phosphorescence emission spectra of 4′-(trifluoromethyl)acetophenone has been studied using pulsed source phosphorimetry. | [Purification Methods]
Purify the ketone by distillation or sublimation in vacuo.[Beilstein 7 IV 1404.] |
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