| Identification | More | [Name]
Glycine methyl ester hydrochloride | [CAS]
5680-79-5 | [Synonyms]
AMINOACETIC ACID METHYL ESTER HYDROCHLORIDE
GLYCINE METHYL ESTER HCL
GLYCINE METHYL ESTER HYDROCHLORIDE
GLYCINE METHYL ESTER HYDROCHLORIDE SALT
GLYCINE METHYL ESTER MONOHYDROCHLORIDE
GLYCINE-OME HCL
L-GLYCINE METHYL ESTER HYDROCHLORIDE
METHYL GLYCINATE HCL
METHYL GLYCINATE HYDROCHLORIDE
N-[(2-Thienyl)Ethyl]-(2S)-2-Chloro-PhenylGlycineMethylEster
Gly-OmeHCl
Glycinemethylesterhydrochloride,99%
Methyl aminoacetate,hydrochloride
Methylglyacinate chlorohydrate
Methyl glutamate
2-Aminoacetic acid methyl·hydrochloride
Glycine methyl·hydrochloric acid | [EINECS(EC#)]
227-139-1 | [Molecular Formula]
C3H8ClNO2 | [MDL Number]
MFCD00012870 | [Molecular Weight]
125.55 | [MOL File]
5680-79-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline | [Melting point ]
175 °C (dec.)(lit.)
| [density ]
1.000 | [storage temp. ]
-20°C | [solubility ]
>1000 g/L (20°C) | [form ]
Powder or Cyrstals | [color ]
White | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
>1000 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [Detection Methods]
T | [BRN ]
3593644 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C3H7NO2.ClH/c1-6-3(5)2-4;/h2,4H2,1H3;1H | [InChIKey]
COQRGFWWJBEXRC-UHFFFAOYSA-N | [SMILES]
C(=O)(OC)CN.Cl | [CAS DataBase Reference]
5680-79-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P271-P261-P280 | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [REACH Registrations]
Active | [HS Code ]
29224995 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline | [Uses]
A Glycine ester, a non-essential amino acid for human development. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
(2) Preparation of glycine methyl ester hydrochloride: 60 mL of methanol was added to a 100 mL round-bottomed flask under ice-bath conditions, followed by the slow dropwise addition of 4 mL of sulfoxide chloride (SOCl2) through a constant-pressure dropping funnel (with a drying tube on top). The resulting off-gas was absorbed using NaOH solution. After stirring the reaction mixture for 1 h, 8 mmol of glycine was added and stirring was continued for 30 min at room temperature. Subsequently, the reaction system was warmed up to 66 °C and refluxed for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) using 2% ninhydrin ethanol solution as a color developer until the disappearance of the raw material spot. After completion of the reaction, the solvent was removed by evaporation to give glycine methyl ester hydrochloride in 100% yield. | [Purification Methods]
Crystallise the ester salt from MeOH. [Werbin & Spoerri J Am Chem Soc 69 1682 1947, Beilstein 4 H 340, 4 III 1116.] | [References]
[1] Synthetic Communications, 1998, vol. 28, # 3, p. 471 - 474
[2] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
[3] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788
[4] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0131
[5] European Journal of Organic Chemistry, 2017, vol. 2017, # 3, p. 695 - 703 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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