| Identification | Back Directory | [Name]
CHLOROTRIANISENE | [CAS]
569-57-3 | [Synonyms]
CSVP
Tace
ADA17
CD156b
Metace
Rianil
Tace-fn
ADAM 17
Anisene
Merbentul
Nsc-10108
TACE, human
Clorestrolo
Clorotrisin
Hormonisene
Chlorotrisin
Chlorestrolo
Trianisestrol
Chlortrianisen
Chlortrianizen
Khlortrianizen
CD156b antigen
Chlorotrianizen
Chlorotrianisine
CHLOROTRIANISENE
Chlortrianisestrol
Chloortrianisestrol
Chlortrianisoestrol
Chlorotrianisene-d9
TNF-alpha convertase
Chlorotrianisene (1 g)
Snake venom-like protease
Tri-p-anisylchloroethylene
CHLOROTRIANISENE USP/EP/BP
chlorotrianisenecrystalline
Tris-(p-methoxyphenyl)ethylene
Tris(p-methoxyphenyl)chloroethylene
chlorotris(p-methoxyphenyl)-ethylen
Chlorotris(p-methoxyphenyl)ethylene
chlorotris(4-methoxyphenyl)ethylene
Ethylene, chlorotris(p-methoxyphenyl)-
1-Chloro-1,2,2-tris(4-methoxyphenyl)ethene
Recombinant Human CD156B/ADAM17 Protein, His Tag
Anti-ADAM 17, C-Terminal antibody produced in rabbit
4,4',4''-(2-chloroethene-1,1,2-triyl)tris(Methoxybenzene)
Anti-ADAM 17 (Cleaved-Arg215) antibody produced in rabbit
1,1',1(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene]
1,1',1''-(2-Chloro-1,1,2-ethenetriyl)tris(4-methoxybenzene)
1,1',1''-(1-Chloro-1,2,2-ethenetriyl)tris[4-methoxybenzene]
1-[2-Chloro-1,2-bis(4-methoxyphenyl)vinyl]-4-methoxybenzene
1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy-benzen
1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-benzen
1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene]
1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene
1,1,1’’-(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxy-benzene]
1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene)
1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxy-benzene
1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene)
Disintegrin and metalloproteinase domain-containing protein 17
Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris*4-methoxy-
Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy- | [EINECS(EC#)]
209-318-6 | [Molecular Formula]
C23H21ClO3 | [MDL Number]
MFCD00048044 | [MOL File]
569-57-3.mol | [Molecular Weight]
380.86 |
| Chemical Properties | Back Directory | [Melting point ]
114-116° | [Boiling point ]
496.07°C (rough estimate) | [density ]
1.1010 (rough estimate) | [refractive index ]
1.4585 (estimate) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
insoluble in H2O; insoluble in EtOH; ≥16.1 mg/mL in DMSO | [form ]
solid | [EPA Substance Registry System]
Chlorotrianisene (569-57-3) |
| Hazard Information | Back Directory | [Originator]
TACE,Merrell ,US ,1952 | [Uses]
Chlorotrianisene USP (TACE) is used to treat Androgen dependent carcinoma of the prostate. | [Uses]
Estrogen. | [Definition]
ChEBI: Chlorotrianisene is a chloroalkene. It has a role as an estrogen receptor modulator, an antineoplastic agent and a xenoestrogen. It derives from a hydride of a stilbene. | [Manufacturing Process]
The following method is described in US Patent 2,430,891. To a solution of 10
parts of tris-p-methoxyphenyl ethylene in 35 to 40 parts of carbon
tetrachloride is added a solution of 2.0 parts of chlorine in 50 parts of carbon
tetrachloride, with stirring, and over a period of ? hour. The carbon
tetrachloride is then removed by distillation on a steam bath and the residual
oil is recrystallized from 250 to 400 parts of methanol, decolorizing with
charcoal or the like if necessary. Tris-p-methoxyphenyl chloroethylene is
obtained in a yield of 65 to 75%. It melts at 113° to 114°C. | [Brand name]
Tace (Sanofi
Aventis). | [Therapeutic Function]
Estrogen | [General Description]
Small white crystals or white powder. Softens at 226°F. Odorless. | [Air & Water Reactions]
Sensitive to prolonged exposure to air and light. Insoluble in water. | [Reactivity Profile]
CHLOROTRIANISENE may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. May react exothermically with both acids and bases. Various catalysts (such as acids) or initiators can cause very exothermic addition polymerization reactions. | [Fire Hazard]
Flash point data for CHLOROTRIANISENE are not available. CHLOROTRIANISENE is probably combustible. | [Biological Activity]
ed50: 2.0 μmglandular kallikrein, a trypsin-like serine protease, has been identified as a major estrogen-induced protein in the rat anterior pituitary. this induction appears to be mediated by increased gene expression since glandular kallikrein mrna is also estrogen-induced. chlorotrianisene is classified as an estrogen agonist. | [in vitro]
the ed50 of chlorotrianisene were lowered by 3.9-fold. chlorotrianisene inhibited the growth of both p388 and p388/adr cells in a concentration-dependent manner [1]. | [in vivo]
chlorotrianisene markedly varied in its ability to elicit agonist responses on the three measures. on uterine weight and anterior pituitary prolactin, chlorotrianisene behaved as partial agonists. chlorotrianisene also exhibited strikingly less agonist activity on glandular kallikrein than on prl or the uterus. further, the small agonist activity of chlorotrianisene on glandular kallikrein induction differed from that on the uterus or prolactin [2]. | [References]
[1] ramu a, glaubiger d, fuks z. reversal of acquired resistance to doxorubicin in p388 murine leukemia cells by tamoxifen and other triparanol analogues. cancer res. 1984 oct;44(10):4392-5.
[2] powers ca, hatala ma, pagano pj. differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene. mol cell endocrinol. 1989 sep;66(1):93-100.
[3] nulsen ro, carmon wb, hendrick ho. tace (chlorotrianisene), a new estrogen for inhibition of lactation. am j obstet gynecol. 1953 may;65(5):1048-51. |
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Moltt Biocem Co., Ltd.
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