| Identification | Back Directory | [Name]
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[(3,4-dichlorophenyl)methoxy]-6-fluoro-, (1R,2R,3R,5R,6R)- | [CAS]
569686-87-9 | [Synonyms]
BCI632
BCI-632
BCI 632
MGS0039
MGS-0039
MGS 0039
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[(3,4-dichlorophenyl)methoxy]-6-fluoro-, (1R,2R,3R,5R,6R)- | [Molecular Formula]
C15H14Cl2FNO5 | [MDL Number]
MFCD32643707 | [MOL File]
569686-87-9.mol | [Molecular Weight]
378.18 |
| Chemical Properties | Back Directory | [Melting point ]
>230 °C (decomp) | [Boiling point ]
526.1±50.0 °C(Predicted) | [density ]
1.65±0.1 g/cm3(Predicted) | [pka]
1.29±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
MGS0039 is a type II group mGluR antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with Ki values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats[1]. | [References]
[1] Chaki S, et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004 Mar;46(4):457-67. DOI:10.1016/j.neuropharm.2003.10.009 |
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