ChemicalBook--->CAS DataBase List--->5697-56-3

5697-56-3

5697-56-3 Structure

5697-56-3 Structure
IdentificationMore
[Name]

Carbenoxolone
[CAS]

5697-56-3
[Synonyms]

CARBENOXOLONE
3-beta-(3-carboxypropionyloxy)-11-oxo-olean-12-en-30-oicacid
3-beta-hydroxy-11-oxo-olean-12-en-30-oicacihydrogensuccinate
biogastrone
bioral
glycyrrhetinic acid hydrogen succinate
3beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate
Olean-12-en-29-oic acid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,(3b,20b)-
3β-[(β-Carboxypropionyl)oxy]-11-oxoolean-12-en-30-oic acid
[EINECS(EC#)]

227-174-2
[Molecular Formula]

C34H52O8
[MDL Number]

MFCD00867458
[Molecular Weight]

588.77
[MOL File]

5697-56-3.mol
Chemical PropertiesBack Directory
[Melting point ]

291-294 °C
[alpha ]

D20 +128° (chloroform)
[Boiling point ]

553.75°C (rough estimate)
[density ]

1.20
[refractive index ]

1.5820 (estimate)
[pka]

pKa 6.7 (Uncertain)
[color ]

Cream crystals
[Water Solubility ]

6.621mg/L(24 ºC)
[CAS DataBase Reference]

5697-56-3(CAS DataBase Reference)
[EPA Substance Registry System]

5697-56-3(EPA Substance)
Hazard InformationBack Directory
[Originator]

Biogastrone,Winthrop,UK,1963
[Uses]

Glucocorticoid.
[Manufacturing Process]

23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.
[Therapeutic Function]

Antiinflammatory (gastric)
[Safety Profile]

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Human systemic effects byingestion: muscle weakness and flaccid paralysis. Whenheated to decomposition it emits acrid smoke and fumes.
Safety DataBack Directory
[Toxicity]

LD50 orl-rat: 2450 mg/kg OYYAA2 19,323,80
5697-56-3 suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Website: www.chemicalbook.com/ShowSupplierProductsList30845/0.htm
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-19930503282 +86-19930503282 , +86-19930503282
Website: https://www.chemicalbook.com/manufacturer/crovell/
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Website: www.bonchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258
Website: www.coreychem.com
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +8618192503167 , +8618192503167
Website: https://www.chemicalbook.com/ShowSupplierProductsList1644393/0.htm
Company Name: Zhuozhou Wenxi import and Export Co., Ltd
Tel: +8613111626072 , +8613111626072
Website: www.wenxichem-pharma.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 0551-65418671
Website: https://www.tnjchem.com
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-29-89586680 +8618192503167 , +8618192503167
Website: www.dideu.com
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: 0571-85134551
Website: www.afinechem.com/index.html
Company Name: Baoji Guokang Bio-Technology Co., Ltd.
Tel: 0917-3909592 13892490616 , 13892490616
Website: www.gk-bio.com
Company Name: Baoji Guokang Healthchem co.,ltd
Tel: +8615604608665 15604608665 , 15604608665
Website: www.gk-bio.com
Company Name: Xi'an ZB Biotech Co.,Ltd
Tel:
Website: www.xazbbio.cn
Company Name: Henan Alfa Chemical Co., Ltd
Tel: +8618339805032 , +8618339805032
Website: https://www.chemicalbook.com/manufacturer/henan-alfa-chemical-570/
Company Name: Hebei baicao biology science and technology co., ltd
Tel: +86-19131911055 +8617824879454 , +8617824879454
Website: www.chemicalbook.com/ShowSupplierProductsList1099453/0.htm
Company Name: LUYUNJIA CHEMISTRY XIAMEN LIMITED
Tel: +86-592-5360779 +86-13055435203 , +86-13055435203
Website: http://www.luyunjiachem.com
Company Name: Hebei Duling International Trade Co. LTD
Tel: +8613126117136 , +8613126117136
Website: www.chemicalbook.com/ShowSupplierProductsList1283525/0.htm
Tags:5697-56-3 Related Product Information
54182-58-0 471-53-4 5697-56-3 1333-74-0 7722-84-1 2375-03-3 7783-06-4 7421-40-1 1914-99-4