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57-64-7

57-64-7 Structure

57-64-7 Structure
IdentificationMore
[Name]

PHYSOSTIGMINE SALICYLATE
[CAS]

57-64-7
[Synonyms]

ESERINE MONOSALICYLATE
ESERINE SALICYLATE
ESERINE SALICYLATE SALT
PHYSOSTIGMINE SALICYLATE
PHYSOSTIGMINE SALICYLATE SALT
2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci
ar-44
physostigmine,[salicylate(1:1)]
physostigmine,salicylate(1:1)
physostolsalicylate
salicylicacid,compd.withphysostigmine(1:1)
tl-1380
trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)
ESERINE SALICYLATE 99.9%
Physostigmine monosalicylate
Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)
PHYSOSTIGMINESALICYLATE,USP
ESERINE SALICYLATE(RG)
Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)
Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
[EINECS(EC#)]

200-343-8
[Molecular Formula]

C22H27N3O5
[MDL Number]

MFCD00135659
[Molecular Weight]

413.47
[MOL File]

57-64-7.mol
Chemical PropertiesBack Directory
[Appearance]

solid
[Melting point ]

181-183 °C
[storage temp. ]

-20°C
[solubility ]

DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
[form ]

neat
[pka]

pKa 1.96/8.08(H2O,t =15) (Uncertain)
[Usage]

Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
[Merck ]

7384
[BRN ]

3900576
[InChIKey]

HZOTZTANVBDFOF-DPKVYHSMNA-N
[SMILES]

C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
[CAS DataBase Reference]

57-64-7(CAS DataBase Reference)
[EPA Substance Registry System]

Physostigmine salicylate (57-64-7)
Safety DataBack Directory
[Hazard Codes ]

T+
[Risk Statements ]

R26/28:Very Toxic by inhalation and if swallowed .
[Safety Statements ]

S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 1544 6.1/PG 1
[WGK Germany ]

3
[RTECS ]

TJ2450000
[HazardClass ]

6.1(a)
[PackingGroup ]

II
[HS Code ]

2939800000
[Safety Profile]

Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.
[Toxicity]

LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)
Hazard InformationBack Directory
[General Description]

Crystal form that turns red on exposure to heat or light.
[Reactivity Profile]

Behaves as a weak acid in solution.
[Health Hazard]

This compound is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.
[Fire Hazard]

When heated to decomposition, PHYSOSTIGMINE, [SALICYLATE (1:1)] emits toxic fumes of nitrogen oxides.
[Chemical Properties]

solid
[Uses]

cholinergic, anticholinesterase, miotic
[Uses]

Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
[Definition]

ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine.
[Brand name]

Antilirium (Forest); Isopto Eserine (Alcon).
[storage]

-20°C
Spectrum DetailBack Directory
[Spectrum Detail]

PHYSOSTIGMINE SALICYLATE(57-64-7)MS
PHYSOSTIGMINE SALICYLATE(57-64-7)1HNMR
PHYSOSTIGMINE SALICYLATE(57-64-7)13CNMR
PHYSOSTIGMINE SALICYLATE(57-64-7)IR1
PHYSOSTIGMINE SALICYLATE(57-64-7)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

57-64-7(sigmaaldrich)
[TCI AMERICA]

Physostigmine Salicylate,>98.0%(T)(57-64-7)
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