| Identification | More | [Name]
2',4'-Dihydroxypropiophenone | [CAS]
5792-36-9 | [Synonyms]
1-(2,4-DIHYDROXYPHENYL)PROPAN-1-ONE
2,4-DIHYDROXYPHENYL ETHYL KETONE
2',4'-DIHYDROXYPROPIOPHENONE
2,4-DIHYDROXYPROPIOPHENONE
4-PROPIONYLRESORCINOL
LABOTEST-BB LT00261298
1-(2,4-Dihydroxyphenyl)-1-propanone
ETHYL 2,4-DIHYDROXYPHENYL KETONE | [EINECS(EC#)]
227-329-4 | [Molecular Formula]
C9H10O3 | [MDL Number]
MFCD00002280 | [Molecular Weight]
166.17 | [MOL File]
5792-36-9.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow crystals or crystalline powder | [Melting point ]
95-98 °C(lit.)
| [Boiling point ]
178 °C / 7mmHg | [density ]
1.1708 (rough estimate) | [refractive index ]
1.5260 (estimate) | [storage temp. ]
RT, stored under nitrogen | [form ]
powder to crystal | [pka]
8.03±0.40(Predicted) | [color ]
Light yellow to Yellow to Orange | [BRN ]
1238635 | [Cosmetics Ingredients Functions]
ANTIOXIDANT | [InChIKey]
LLBBBYLDTDJMNU-UHFFFAOYSA-N | [CAS DataBase Reference]
5792-36-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29145090 |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow crystals or crystalline powder | [Uses]
2',4'-Dihydroxypropiophenone is an organic synthesis intermediate used in the pharmaceutical industry to manufacture the neurostimulant Resulin (dimethylformin). | [Preparation]
Preparation by reaction of propionic acid with resorcinol,
in the presence of zinc chloride (Nencki reaction), at reflux (160–165°) ? for 15 min, at 150° for 20 min
in the presence of boron trifluoride for 2 h at 70° (79%), at 80° (67%) ? or at 105–108° for 15 min (71%)
in the presence of polyphosphoric acid for 10–20 min in a boiling water bath ? (65%)
in the presence of 70% perchloric acid at reflux for 30 min (70%)
in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid type) ? at 160° for 2–3 h (76%)
Preparation by reaction of propionitrile with resorcinol (Hoesch reaction) (75%) (65%) (46%)(35%)
Preparation by reaction of propionic anhydride with resorcinol
in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid ? type) at 160° for 2–3 h (82%)
in the presence of concentrated sulfuric acid (small drops) at 130° for some ? min (60%)
Also obtained by Fries rearrangement of resorcinol dipropionate
with aluminium chloride at 180–185° for 90 min (25%)
with boron trifluoride, in the presence of resorcinol, at 75° for 1 h (83%)
Also obtained by reaction of ethylmagnesium bromide with 2,4-dihydroxy-N, N-diethylbenzamide in refluxing benzene (12%). |
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