ChemicalBook--->CAS DataBase List--->40957-83-3

40957-83-3

40957-83-3 Structure

40957-83-3 Structure
IdentificationMore
[Name]

Glycitein
[CAS]

40957-83-3
[Synonyms]

4',7-DIHYDROXY-6-METHOXYISOFLAVONE
4,7-DIHYDROXY-6-METHOXYISOFLAVONE
7,4'-DIHYDROXY-6-METHOXYISOFLAVONE
GLYCETEIN
GLYCITEIN
Glicetein
7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-
7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-chromen-4-one
GLYCITEIN,FROMSOYBEAN
4μ,7-Dihydroxy-6-methoxyisoflavone, Glycetein
3-(4-Hydroxyphenyl)-6-methoxy-7-hydroxy-4H-1-benzopyran-4-one
[Molecular Formula]

C16H12O5
[MDL Number]

MFCD00016679
[Molecular Weight]

284.26
[MOL File]

40957-83-3.mol
Chemical PropertiesBack Directory
[Melting point ]

>300°C
[Boiling point ]

547.4±50.0 °C(Predicted)
[density ]

1.420±0.06 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

Aqueous Base (Slightly), DMSO (Slightly)
[form ]

Solid
[pka]

7.03±0.20(Predicted)
[color ]

Light Brown
[Usage]

The compund shows an anti-cancer activity, plasma cholesterol reduction, reduction in postmenopausal bone loss
[InChIKey]

DXYUAIFZCFRPTH-UHFFFAOYSA-N
[CAS DataBase Reference]

40957-83-3(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Safety Statements ]

24/25
[WGK Germany ]

3
[HS Code ]

29329990
Hazard InformationBack Directory
[Description]

Glycitein is an O-methylated isoflavone that comprises 5-10% of the total isoflavones in soy food products. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro with an IC50 value of 3.94 μM. It suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor. It has also been used to attenuate proliferation (10 μM) of aortic smooth muscle cells related to atherosclerotic vascular change in stroke-prone hypertensive rats and to protect against beta amyloid (Aβ)-induced toxicity and oxidative stress (100 μg/ml) in C. elegans expressing human Aβ.
[Chemical Properties]

Pale Orange Solid
[Uses]

Glycitein has been used as standard for the analysis of soy isoflavones and metabolites in urine. It has also been used to bind to recombinant estrogen and progesterone receptors to know the relative binding affinity (RBA) for detection of potential endocrine disruptors.
[Uses]

Glycitein may be used as a reference standard in the determination of glycitein in hydrolyzed dry soya extracts using reversed-phase high-performance liquid chromatography (RP-HPLC).
[Uses]

The compund shows an anti-cancer activity, plasma cholesterol reduction, reduction in postmenopausal bone loss
[Definition]

ChEBI: A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 7 and 4'. It has been isolated from the mycelia of the fungus Cordyceps sinensis.
[General Description]

Glycitein is an isoflavone found in soy food products.
[Biochem/physiol Actions]

Glycitein is a soybean (yellow cultivar) isoflavonoid; its natural glycosides are synergistic with genistein in inducing specific gene expression. Glycitein may be used to study anti-oxidation processes at the level of gene transcription where it increases the binding of transcription factors [nuclear factor-E2-related factor 2 (Nrf2) and c-Jun] to the antioxidant response element (ARE) on HO-1 and NQO1 promoters. Glycitein may be used in combination with other isoflavonoids such as genistein and daidzein to study apoptosis.
Spectrum DetailBack Directory
[Spectrum Detail]

Glycitein(40957-83-3)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

40957-83-3(sigmaaldrich)
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