| Identification | Back Directory | [Name]
ICA 069673 | [CAS]
582323-16-8 | [Synonyms]
ICA 069673
ICA069673;ICA-069673
ICA-069673 >=98% (HPLC)
N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro- | [Molecular Formula]
C11H6ClF2N3O | [MDL Number]
MFCD20926351 | [MOL File]
582323-16-8.mol | [Molecular Weight]
269.63 |
| Chemical Properties | Back Directory | [Boiling point ]
358.9±37.0 °C(Predicted) | [density ]
1.539±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM) | [form ]
Powder | [pka]
9.47±0.70(Predicted) | [color ]
White to off-white | [InChI]
1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18) | [InChIKey]
IIBSHMFXVWTQSJ-UHFFFAOYSA-N | [SMILES]
O=C(C1=CC=C(F)C(F)=C1)NC2=CN=C(Cl)N=C2 |
| Hazard Information | Back Directory | [Description]
ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy. | [Uses]
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells[1][2]. | [storage]
Room temperature | [References]
[1] Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301. DOI:10.1124/jpet.115.225268 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|